自体富血小板血浆治疗骨科损伤相关疾病的临床应用  

Clinical Application of A utologous Platelet-Rich Plasma in the Treatment of Ort hopaedic Inj ury-Related Disorders

作　　者：姚鹏程 马斌祥[2] 关永林[2] 李振豪 常斌 张思源 YAO Peng-cheng;MA Bin-xiang;GUAN Yong-lin;LI Zhen-hao;CHANG Bin;ZHANG Si-yuan(Gansu University of Traditional Chinese Medicine,Lanzhou,730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou,730050,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中医院,兰州730000

出　　处：《神经药理学报》2023年第2期59-64,共6页Acta Neuropharmacologica

基　　金：甘肃省卫生健康行业科研计划项目(No.GSWSKY2022-43)。

摘　　要：富血小板血浆(platelet-rich plasma,PRP)是由自体血经过离心分离后得到主要含有高浓度的血小板、白细胞及纤维蛋白的血小板血浆浓缩物,被激活后可释放大量细胞生长因子(growth factors,GFs)和细胞因子,经研究证实PRP可有效降低炎症反应、促进组织合成、具有极强的再生潜在能力。丰富的生长因子和细胞因子在软组织再生微环境启动和调节中具有重要作用。骨科临床治疗常中会遇到由创伤、运动相关或其他类型的创伤引起的周围神经损伤、骨缺损、肌肉韧带损伤、关节软骨疾病及慢性不愈合伤口等骨科损伤相关疾病,通常需手术治疗,但由于损伤后局部血运较差等多种原因,导致术后患者恢复并不理想。该文对近期PRP治疗骨科损伤相关疾病的应用进行综述,探讨PRP对治疗骨科损伤相关疾病的未来研究,并为临床治疗提供参考。Platelet-rich plasma(PRP)is a platelet plasma concentrate containing mainly high concentrations of platelets,leukocytes and fibrin.obtained by centrifugation of autolo-gous blood,which is activated to release large amounts of cell growth factors(GFs)and cyto-kines,and has been shown to be effective in reducing inflammatory responses.promoting tissue anabolic capacity and having a strong regenerative potential.The abundance of growth factors and cytokines plays an important role in the initiation and regulation of the soft tissue regenerative microenvironment.Peripheral nerve injuries,bone defects,muscle ligament injuries,articular cartilage disease and chronic non-healing wounds caused by trauma,sportsrelated or other types of trauma are commonly encountered in orthopaedic clinical practice and often require surgical treatment.This article reviews the recent use of PRP in the treatment of orthopaedic injury-related disorders and discusses future research on the use of PRP in the treatment of orthopaedic injury-related disorders and provides a reference for clinical treatment.

关 键 词：富血小板血浆 骨科损伤 研究进展 

分 类 号：R964[医药卫生—药理学]