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作 者:王睿 黄建平[1] 李江[2] 连鑫博 张北斗[1] 王丹凤 赵颖洁 Wang Rui;Huang Jianping;Li Jiang;Lian Xinbo;Zhang Beidou;Wang Danfeng;Zhao Yingjie(College of Atmospheric Sciences,Key Laboratory for Semi-Arid Climate Changes of the Ministry of Education,Collaborative Innovation Center for Western Ecological Safety,Lanzhou University,Lanzhou 730000,China;National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
机构地区:[1]兰州大学大气科学学院,半干旱气候变化教育部重点实验室,西部生态安全省部共建协同创新中心,甘肃兰州730000 [2]中国医学科学院北京协和医学院,国家癌症中心,肿瘤医院,北京100021
出 处:《兰州大学学报(医学版)》2023年第9期63-72,共10页Journal of Lanzhou University(Medical Sciences)
基 金:兰州大学中央高校基本科研业务费专项基金资助项目(lzujbky-2022-kb09);广州实验室自立资助项目(SRPG22-007);甘肃省知识产权计划(定向组织)资助项目(22ZSCQD02)。
摘 要:新型冠状病毒自2019年底首次暴发,在全球肆虐3年,对人类健康、经济和社会造成极大影响。虽然世界卫生组织2023年5月已宣布新型冠状病毒感染疫情不再构成国际关注的突发公共卫生事件,但随着病毒的变异及人群免疫水平的变化,重复感染率持续上升,给疫情防控和疾病治疗带来极大挑战。明确新冠病毒重复感染风险,对于预防再感染至关重要。本文分析总结2020年1月1日-2023年9月1日国内外文献报道的新冠病毒重复感染风险及其影响因素,为有效控制新冠病毒重复感染提供参考。Omicron变异株导致的重复感染率最高,但重症及死亡率较低。重复感染的累积风险和疾病负担随着感染次数的增加而增加。年龄、病毒变异、免疫水平以及个人防护是影响重复感染的重要因素。建议动态监测重复感染的发生风险,识别重复感染的高风险人群,制定重复感染的预防策略,以有效控制疫情的发展和蔓延。Severe acute respiratory syndrome corona virus 2(SARS-CoV-2)first broke out in late 2019 and raged around the world for three years,causing significant impacts on human health,economy and society.Although the World Health Organization declared the end of the global health emergency status for COVID-2019 in May 2023,its reinfection rate continued to rise along with the virus mutation and changes in population immunity levels,which has posed a great challenge to epidemic prevention and control as well as disease treatment.The identification of COVID-2019 reinfection risk is critical to preventing the reinfection detriment.This review analyzed and summarized the reinfection risk of SARS-CoV-2 and its influencing factors in the literature in China and abroad from January 1,2020 to September 1,2023,aiming at providing reference for the effective control of SARS-CoV-2 reinfection.The Omicron variant was found to cause the highest rate of reinfection,but was associated with lower severity and mortality.The cumulative risk of reinfection and disease burden increased with the number of infections.Age,virus mutation,immunity level and personal protection were important factors affecting reinfection.It is necessary to dynamically monitor the risk of reinfection,identify high-risk groups of reinfection,develop prevention strategies for reinfection and effectively control the development and spread of the epidemic.
关 键 词:新型冠状病毒 重复感染 Omicron变异株 危险因素
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