顺式-二氯[(1R,2R)-(-)-环己二胺]合铂(Ⅱ)的合成与结构表征  

Synthesis and structural characterization of cis-dichloro[(1R,2R)-(-)-cyclohexanediamine]platinum(Ⅱ)

作　　者：高安丽[1] 郭旭虎 余娟[1] 周鹏[2,3] GAO Anli;GUO Xuhu;YU Juan;ZHOU Peng(State key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming 650106,China;Department of Pharmacy,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China;School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming 650500,China)

机构地区：[1]昆明贵金属研究所稀贵金属综合利用新技术国家重点实验室,昆明650106 [2]昆明医科大学第二附属医院药学部,昆明650101 [3]昆明医科大学药学院云南省天然药物药理重点实验室,昆明650500

出　　处：《贵金属》2023年第S01期100-106,共7页Precious Metals

基　　金：云南省基础研究专项面上项目(202001AT070090);云南省技术创新人才项目((202305AD160019);云南省转制科研院所技术开发研究专项(202104AR040016);云南省科技计划项目(202102AB080007);云南贵金属实验室科技计划项目(YPML-2022050231)。

摘　　要：顺式-二氯[(1R,2R)-(-)-环己二胺]合铂是一种铂类抗癌药物及一种合成药效基团为(1R,2R)-(-)-环己二胺的铂类抗癌药物的中间体。通过两种常规方法合成了顺式-二氯[(1R,2R)-(-)-环己二胺]合铂,产率均高达90%以上,并采用元素分析、核磁共振谱、红外光谱及X-射线单晶衍射分析对其进行了结构表征。结果表明:此化合物的单晶结构含有1分子结晶水,为单斜晶系,C2空间群,晶胞参数为:a=12.753(3)nm,b=6.8749(16)nm,c=12.325(3)nm,α=90°,β=97.577(3)°,γ=90°,V=1071.1(4)nm^(3),Z=4,Pt-N键长分别为2.047和2.027 nm,Pt-Cl键长分别为2.326和2.330 nm,且Pt^(2+)、N和Cl不在同一平面上,可能与结晶水、两个交错排列的分子间N-H···Cl氢键的存在有关。Cis-dichloro[(1R,2R)-(-)-cyclohexanediamine]platinum(Ⅱ)is an anticancer drug or an intermediate for the synthesis of many anticancer drugs with the carrier group(1R,2R)-(-)-cyclohexanediamine.It was synthesized by two conventional methods with a yield of above 90%and characterized by elemental analysis,1H-and 13C-NMR,IR and X-ray single crystal diffraction analysis.The single-crystal structure cultivated by a solvent evaporation method contains one crystallization water molecule,belongs to monoclinic crystal system and C2 space group,the unit cell parameters are a=12.753 nm,b=6.8749 nm,c=12.325 nm,α=90°,β=97.577°,γ=90°,V=1071.1 nm^(3),Z=4,Pd-N bond lengths are 2.047 and 2.027 nm as well as Pd-Cl are 2.326 and 2.330 nm,respectively,and Pt^(2+),N and Cl is not on the same plane,which may be due to the presence of one crystallization water molecule and N-H···Cl hydrogen-bond between two staggered molecules.

关 键 词：顺式-二氯[(1R 2R)-(-)-环己二胺]合铂 抗癌药物 合成 结构表征 

分 类 号：O627.8[理学—有机化学]