基于“恶性循环”假说探讨支气管扩张症中医治疗思路  

Discussion on the Treatment of Bronchiectasis in Traditional Chinese Medicine based on Hypothesis of “Vicious Circle”

作　　者：张海艳 石霞 周瑞玲 王冰[2] 苗青[2] ZHANG Haiyan;SHI Xia;ZHOU Ruiling;WANG Bing;MIAO Qing(Graduate School of Beijing University of Chinese Medicine,Beijing,100029;Xiyuan Hospital, China Academy of Chinese Medical Sciences)

机构地区：[1]北京中医药大学研究生院,北京朝阳100029 [2]中国中医科学院西苑医院

出　　处：《中医杂志》2023年第21期2188-2191,2196,共5页Journal of Traditional Chinese Medicine

基　　金：中国中医科学院创新工程(CI2021A01101,CI2021A01103);北京市科技计划课题(Z181100001718119);北京中医药薪火传承“3+3”工程室站建设项目(2019-SZ-C-77)。

摘　　要：支气管扩张症存在宿主防御损害、气道黏液清除障碍、细菌定植、感染和炎症之间的“恶性循环”,导致患者反复急性加重、生活质量低下。基于“恶性循环”假说,从三个方面探讨中医治疗支气管扩张症的思路:首先,治“痰”,改善气道黏液高分泌状态,廓清气道是该病治疗的基础;其次,补脾扶正,提高患者机体免疫功能,减少反复感染和急性发作频率;最后,清热泻肺,减轻感染和炎性损伤。打破该病的“恶性循环”过程,以期延缓疾病进展、减少急性加重、提高患者生活质量。Bronchiectasis is characterized by a “vicious cycle” involving compromised host defense,impaired clearance of airway mucus,bacterial colonization,infections,and inflammation,leading to frequent acute exacerbations and diminished quality of life.Based on the hypothesis of “vicious circle”,this paper explores the treatment of bronchiectasis by traditional Chinese medicine(TCM) from three aspects.Firstly,dissipating excessive “phlegm/sputum” secretion and enhancing airway clearance form the foundation of the treatment,aiming to improve the condition of mucus hypersecretion.Secondly,invigorating spleen for strengthening vital energy can improve the function of immune system and reduce recurrent infections and acute attacks.Lastly,clearing heat and purging the lung can alleviate infection and inflammatory damage.By employing these methods,TCM can disrupt the progression of the “vicious circle”,delaying disease advancement,minimizing acute exacerbations,and improving the quality of life for patients.

关 键 词：支气管扩张症 化痰 补脾 清热泻肺 “恶性循环”假说 

分 类 号：R259[医药卫生—中西医结合]