基于数据挖掘探讨中药内服方治疗带状疱疹后遗神经痛用药规律  

Discussion on medication law of TCM oral prescriptions for postherpetic neuralgia based on data mining

作　　者：张则润 杨继国[2] 刘源香[3] Zhang Zerun;Yang Jiguo;Liu Yuanxiang(the First Clinical College,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;College of Acupuncture and Massage,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Introneurosis,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250355 [2]山东中医药大学针灸推拿学院,济南250014 [3]山东中医药大学附属医院神经内一科,济南250014

出　　处：《国际中医中药杂志》2023年第11期1453-1457,共5页International Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2019-0178)。

摘　　要：目的分析中药内服方治疗带状疱疹后遗神经痛(PHN)的用药规律。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)2002年1月1日-2021年12月31日有关中药内服方治疗PHN的有效验案与临床研究文献,通过古今医案云平台统计用药频次、药物属性,并进行关联分析、聚类分析与复杂网络分析。结果共纳入文献233篇,涉及处方243首,包括中药191味,使用频次>40的中药有20味,以活血化瘀药为主,亦较多应用具有清热解毒功效之药,用药药性以温、平、微寒、寒为主,药味以苦、辛、甘为主,归经主要归肝、脾、心经。关联规则分析得到常用中药组合15组,常用中药可聚为4类,复杂网络分析得到核心用药处方为当归、甘草、延胡索、柴胡、红花、白芍、桃仁、川芎、生地黄。结论中药内服治疗PHN重视活血化瘀、通络止痛,兼顾清解瘀热、调和气血。Objective To analyze the medication law of TCM oral prescriptions in the treatment of postherpetic neuralgia(PHN).Methods The effective cases and clinical studies about TCM oral prescriptions in the treatment of PHN were retrieved from CNKI,Wanfang Data,VIP,and CBM from January 1,2002 to December 31,2021.The medication frequency and drug properties were counted through the Ancient and Modern Medical Record Cloud Platform,and correlation analysis,cluster analysis and complex network analysis were performed.Results A total of 233 articles were included,involving 243 prescriptions and 191 kinds of Chinese materia medica.There were 20 kinds of Chinese materia medica with frequency>40,most of which have the efficacy of promoting blood circulation to remove blood stasis.The Chinese materia with heat-clearing and detoxifying efficacy were also often used.The properties were mainly warm,mild,slight cold,and cold,tastes were mainly bitter,pungent and sweet,and meridians were mainly liver,spleen and heart meridians.The association rule analysis was used to obtain 15 commonly used TCM groups.The commonly used Chinese materia medica could be clustered into 4 categories.The core prescription obtained by complex network analysis was Angelicae Sinensis Radix,Glycyrrhizae Radix et Rhizoma,Corydalis Rhizoma,Bupleuri Radix,Carthami Flos,Paeoniae Radix Alba,Persicae Semen,Chuanxiong Rhizoma,and Rehmanniae Radix.Conclusion TCM oral prescriptions for the treatment of PHN put promoting blood circulation to remove blood stasis and activating meridians to stop pain in priority,taking into account the clearing heat,regulating qi and blood.

关 键 词：神经痛 疱疹后 古今医案云平台 内服方 用药规律 数据挖掘 

分 类 号：R275[医药卫生—中医皮科]