环泊酚与丙泊酚用于妇科全身麻醉手术的安全性与有效性:meta分析  

Safety and efficacy of ciprofol and propofol for gynecologic surgery with general anesthesia:a meta-analysis

作　　者：许云鹏 冷玉芳[1,2] 韩雪娜[3] 昌淑婷 陈明明 郭鸿[4] 刘健 Xu Yunpeng;Leng Yufang;Han Xuena;Chang Shuting;Chen Mingming;Guo Hong;Liu Jian(The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,China;Department of Anesthesiology,First Hospital of Lanzhou University,Lanzhou 730000,China;Day Surgery Center,The First Hospital of Lanzhou University,Lanzhou 730000,China;Department of ICU,the First Hospital of Lanzhou University,Lanzhou 730000,China;Gansu Province Maternity and Child-Care Hospital(Gansu Provincial Central Hospital),Lanzhou 730070,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院麻醉科,兰州730000 [3]兰州大学第一医院日间手术中心,兰州730000 [4]兰州大学第一医院重症医学科,兰州730000 [5]甘肃省妇幼保健院(甘肃省中心医院),兰州730070

出　　处：《中华麻醉学杂志》2023年第9期1087-1092,共6页Chinese Journal of Anesthesiology

摘　　要：目的采用meta分析方法评价环泊酚与丙泊酚用于妇科全身麻醉手术的安全性和有效性。方法计算机检索PubMed、Embase、Cochrane、Web of Science、CNKI、Wanfang Data、CBM、VIP等数据库,纳入比较环泊酚与丙泊酚用于妇科全身麻醉手术安全性和有效性的随机对照试验,检索时限为建库至2023年5月,采用Revman 5.4软件进行meta分析。结果共纳入6项随机对照试验,共741例患者,其中371例患者使用环泊酚,370例患者使用丙泊酚。与丙泊酚组相比,环泊酚组麻醉苏醒时间延长,麻醉诱导前后MAP、SBP和DBP差值降低,注射痛、呼吸抑制、体动和低血压发生率降低(P<0.05)。2组麻醉诱导成功时间,麻醉诱导前后BIS值、HR差值及心动过速、心动过缓、高血压发生率比较差异无统计学意义(P>0.05)。结论环泊酚用于妇科全身麻醉手术的有效性与丙泊酚相似,安全性优于丙泊酚。Objective To evaluate the safety and efficacy of ciprofol and propofol for gynecological surgeries with general anesthesia through a meta-analysis.Methods Electronic databases including PubMed,Embase,Cochrane,Web of Science,China National Knowledge Infrastructure,Wanfang Data,China Biomedical Literature Database,and China Science and Technology Journal Database were searched for randomized controlled trials comparing the safety and efficacy of ciprofol and propofol in gynecological surgeries with general anesthesia from inception to May 2023.Meta-analysis was performed using Revman 5.4 software.Results Six randomized controlled trials were included,involving 741 patients,of which 371 received ciprofol and 370 received propofol.Compared with propofol group,the emergence time was significantly prolonged,the difference in mean arterial blood pressure,systolic blood pressure and diastolic blood pressure before and after anesthesia induction was decreased,and the incidence of injection pain,respiratory depression,body movement and hypotension was decreased in ciprofol group(P<0.05).There were no significant differences between the two groups in terms of time of successful anesthesia induction,difference in BIS values and heart rate before and after anesthesia induction,and incidence of tachycardia,bradycardia and hypertension(P>0.05).Conclusions Ciprofol is comparable to propofol in terms of efficacy and has better safety than propofol when used in gynecologic surgeries with general anesthesia.

关 键 词：催眠药和镇静药 麻醉 全身 META分析 

分 类 号：R614.2[医药卫生—麻醉学]