草乌甲素的镇痛机制及其治疗疼痛的研究进展  

Research progress on analgesic mechanism of bulleyaconitine A and its treatment of pain

作　　者：徐海 姚旌 XU Hai;YAO Jing(College of Anesthesiology,Guizhou Medical University,Guiyang 550004,China;Department of Pain,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学麻醉学院,贵州贵阳550004 [2]贵州医科大学附属医院疼痛科,贵州贵阳550004

出　　处：《现代药物与临床》2023年第10期2639-2644,共6页Drugs & Clinic

基　　金：贵州省科技计划项目(黔科合基础-ZK[2023]一般389)。

摘　　要：草乌甲素具有良好的镇痛作用,用于多种疼痛的治疗。草乌甲素可作用于疼痛感知通路中的多个位点,发挥外周、中枢及其他镇痛机制。草乌甲素的临床治疗涉及到骨关节疼痛、癌性疼痛、带状疱疹相关性疼痛、急性疼痛和其他疼痛。对草乌甲素的镇痛机制和治疗各类疼痛的临床应用进行综述,以期对草乌甲素的临床治疗提供参考。Bulleyaconitine A has good analgesic effects and is used for treatment of various types of pain.Bulleyaconitine A can act on multiple targets in the pain perception pathway,playing a role in peripheral,central,and other analgesic mechanisms.The clinical treatment of bulleyaconitine A involves joint pain,cancer pain,herpes zoster associated rash pain,acute pain,etc.This article reviews the analgesic mechanism and clinical application of bulleyaconitine A in treatment of various types of pain,in order to provide reference for the clinical treatment of bulleyaconitine A.

关 键 词：草乌甲素 外周镇痛 中枢镇痛 骨关节疼痛 癌性疼痛 带状疱疹相关性疹痛 急性疼痛 

分 类 号：R285[医药卫生—中药学]