离子液体在经皮给药系统中的应用研究进展  

Research progress in the application of ionic liquids in transdermal drug delivery system

作　　者：闫巧 李方琴 王芳 秦祉剑 杭凌宇 薛玉叶 袁海龙 YAN Qiao;LI Fang-qin;WANG Fang;QIN Zhi-jian;HANG Ling-yu;XUE Yu-ye;YUAN Hai-long(Department of Pharmacy,Air Force Medical Center,PLA,Beijing 100142,China;College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]中国人民解放军空军特色医学中心药学部,北京100142 [2]成都中医药大学药学院,成都611137

出　　处：《中国新药杂志》2023年第20期2073-2079,共7页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(81873092,82174074)。

摘　　要：离子液体(ionic liquids,ILs)是一类在室温或接近室温条件下呈液态的盐。由于其具有易于制备、稳定性好、溶解能力强和结构可调等优点,在生物医学特别是经皮给药方面得到了广泛的研究。ILs可以改善药物溶解度、促进药物经皮渗透、提高药物疗效、解决药物经皮递送存在的问题。本文综述了ILs的分类、合成方法以及ILs在经皮给药中的应用,并归纳了基于ILs的经皮给药制剂,以期为ILs在经皮给药中的深入研究和发展提供借鉴。Ionic liquids(ILs)are a class of salts that appear liquid form at or near room temperature.They are widely used in biomedicine,especially in transdermal drug delivery,because of their simple preparation process,high stability,good solubility and flexible structure.ILs can improve drug solubility,promote transdermal penetration,improve the efficacy of drugs,and solve the problems existing in the transdermal drug delivery.This article reviewed the classification,synthesis methods and its application in transdermal drug delivery.The IL⁃based transdermal preparation was also summarized,in order to provide reference for further research and development of ILs in transdermal drug delivery.

关 键 词：离子液体 经皮给药 促渗 溶解度 抗菌 给药剂型 

分 类 号：R944.1[医药卫生—药剂学]