2型糖尿病对周围动脉疾病侧支动脉生成的影响  

Effect of Type 2 Diabetes Mellitus on Collateral Arteriogenesis in Peripheral Arterial Disease

作　　者：谷娇娇(综述) 高怀林(审校)[1,2] GU Jiao-jiao;GAO Huai-lin(Hebei Yiling Hospital,Shijiazhuang 050091,China;Hebei University of Chinese Medicine,Shijiazhuang 050090,China)

机构地区：[1]河北以岭医院,石家庄050091 [2]河北中医学院,石家庄050090

出　　处：《微循环学杂志》2023年第4期90-93,共4页Chinese Journal of Microcirculation

基　　金：河北省自然科学基金资助项目(H2019106062);河北省重点研发计划项目(223777155D);河北省中医药管理局科研计划项目(2023179)。

摘　　要：2型糖尿病(T2DM)是周围动脉疾病(PAD)的重要发病因素,且对于PAD患者侧支动脉生成有重要影响,如通过降低内皮细胞对流体剪切力(FSS)敏感性、减少对单核/巨噬细胞的招募、阻碍平滑肌细胞增殖迁移等致使侧支动脉生成障碍。关注其相关进展可为临床治疗T2DM合并PAD提供思路。Type 2 diabetes mellitus(T2DM)is an important pathogenetic factor in peripheral arterial disease(PAD)and has a significant impact on collateral arteriogenesis in patients with PAD.For example,it impairs collateral arteriogenesis by decreasing the sensitivity of endothelial cells to fluid shear stress(FSS),decreasing the recruitment of monocytes/macrophages,and impeding the proliferation and migration of smooth muscle cells.Attention to its related progress may provide ideas for clinical treatment of T2DM combined with PAD.

关 键 词：2型糖尿病 周围动脉疾病 动脉生成 

分 类 号：R587.1[医药卫生—内分泌]