人造石英石板材加工矽肺患者的炎性因子表达分析  

Expression analysis of inflammatory factors in artificial quartz stone plate processing silicosis patients

作　　者：任艳 李国辉[2] 余珉 杨丹 冯玲芳 陈钧强 Ren Yan;Li Guohui;Yu Min;Yang Dan;Feng Lingfang;Chen Junqiang(School of Public Health,Hangzhou Medical College(Zhejiang Academy of Medical Sciences),Hangzhou 310013,China;Department of Occupational Medicine,Hangzhou Red Cross Hospital,Hangzhou 310005,China)

机构地区：[1]杭州医学院公共卫生学院(浙江省医学科学院),杭州310013 [2]杭州市红十字会医院职业病科,杭州310005

出　　处：《中华劳动卫生职业病杂志》2023年第10期837-840,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：浙江省医学支撑学科劳动卫生学(11-ZC02);浙江省公益技术应用研究项目(2017C33048);浙江省医药卫生科技计划项目(2020RC006)。

摘　　要：目的:探讨肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素1β(IL-1β)在人造石英石板材加工矽肺患者血浆和肺泡灌洗液中的水平。方法:于2022年1月,回顾性选取2019年6月至2021年12月浙江省某医院收治的30例矽肺患者为病例组,其中10例人造石英石板材加工矽肺患者和20例其他类型矽肺患者;并选择同期健康体检者30例为对照组,收集所有研究对象血浆和所有患者肺泡灌洗液,采用酶联免疫吸附试验检测血浆和肺泡灌洗液中TNF-α、IL-6、IL-1β的含量,并进行统计学分析。结果:与对照组比较,矽肺患者血浆中TNF-α、IL-6、IL-1β的含量更高(P<0.05),且人造石英石板材加工矽肺患者血浆中TNF-α、IL-1β的水平高于其他类型矽肺患者(P<0.05)。人造石英石板材加工矽肺患者血浆中TNF-α和IL-1β的含量高于相同分期的其他类型矽肺患者(P<0.05)。人造石英石板材加工矽肺患者肺泡灌洗液中的IL-1β含量高于其他类型矽肺患者(P<0.05)。结论:人造石英石板材加工矽肺患者TNF-α、IL-6、IL-1β的水平较其他类型矽肺患者更高,可能与接触的粉尘组分有关。Objective To investigate the levels of tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6)and interleukin-1beta(IL-1β)in the plasma and bronchoalveolar lavage fluid of silicosis patients with artificial quartz stone plate processing.Methods In January 2022,10 patients with artificial quartz stone plate processing silicosis and 20 patients with common silicosis who were hospitalized and diagnosed in a hospital at Zhejiang Province from June 2019 to December 2021 were retrospectively selected as the research objects,and 30 healthy people were selected as the control group during the same period.Plasma of all subjects and bronchoalveolar lavage fluid of all patients were collected.The levels of TNF-α,IL-6 and IL-1βin plasma and bronchoalveolar lavage fluid were detected by enzyme-linked immunosorbent assay and were analyzed.Results The levels of TNF-α,IL-6 and IL-1βin the plasma of patients with silicosis were higher than those of the control group(P<0.05),and the levels of TNF-αand IL-1βin the plasma of silicosis patients with artificial quartz stone plate processing were higher than those of common silicosis patients(P<0.05).The levels of TNF-αand IL-1βin plasma of artificial quartz stone plate processing silicosis patients were higher than those of common silicosis patients at the same silicon stage(P<0.05).The levels of IL-1βin bronchoalveolar lavage fluid of silicosis patients with artificial quartz stone plate processing was higher than that of patients with common silicosis(P<0.05).Conclusion The levels of TNF-α,IL-6 and IL-1βin silicosis patients with artificial quartz stone plate processing are higher than those in patients with common silicosis,which may be related to dust components they are exposed to.

关 键 词：矽肺 人造石英石 肿瘤坏死因子Α 白细胞介素6 白细胞介素1Β 

分 类 号：R135.2[医药卫生—劳动卫生]