穴位液氮冷冻疗法对支气管哮喘缓解期肺气虚证患者神经-内分泌-免疫网络系统的影响  

Effects of acupoint liquid nitrogen cryotherapy on neuro-endocrine-immune network system of patients with lung qi deficiency syndrome in bronchial asthma remission stage

作　　者：玉苏甫·吐尔逊[1] 哈力甫·阿布拉[1] 亚森江·买买提 王琦安 厉馨 苏丽亚·艾尔肯 YUSUP·Tursun;HALIP·Abula;YASEN JIANG·Maimaiti;WANG Qi'an;LI Xin;SULIYA·Aierken(People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830011,China)

机构地区：[1]新疆维吾尔自治区人民医院,乌鲁木齐830011

出　　处：《中华中医药杂志》2023年第11期5612-5616,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：新疆维吾尔自治区自然科学基金项目(No.2021D01C182)。

摘　　要：目的:观察穴位液氮冷冻疗法对支气管哮喘缓解期肺气虚证神经-内分泌-免疫网络系统的影响,探讨其可能的作用机制。方法:将100例支气管哮喘患者随机分为对照组和观察组,每组50例。对照组予以布地奈德喷雾剂吸入治疗,观察在对照组基础上配合穴位液氮冷冻治疗,每年2次,2次为1个疗程,随访1年,另50名健康志愿者为健康组,健康组不予任何治疗,检测各组治疗前后血清免疫球蛋白A、G、E(IgA、IgG、IgE)、血清细胞因子[白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ]、血浆神经递质[P物质(SP)、血管活性肠肽(VIP)]的含量。结果:治疗前,与健康组比较,观察组和对照组IgA、IgG、IL-10、IFN-γ及VIP含量显著降低,IgE、IL-4、TNF-α及SP含量显著升高(P<0.05);治疗后,与本组治疗前比较,观察组和对照组IgA、IgG、IL-10、IFN-γ及VIP含量显著升高(P<0.05),且观察组高于对照组(P<0.05),观察组和对照组IgE、IL-4及SP含量显著降低(P<0.05),且观察组低于对照组(P<0.05)。结论:穴位液氮冷冻疗法可能通过改善机体免疫功能,调控细胞因子的释放,调节神经介质,从而起到防治支气管哮喘的作用。Objective:To observe the effect of acupoint liquid nitrogen cryotherapy on the neuro-endocrine-immune network system of lung qi deficiency syndrome during the remission period of bronchial asthma and explore its possible mechanism.Methods:A total of 1o0 patients with bronchial asthma were randomly divided into control group and observation group,with 50 cases in each group.The control group was given budesonide spray inhalation treatment,combined with acupoint liquid nitrogen freezing treatment,twice a year for a course of treatment,followed up for I year.The other 50 healthy volunteers were included in the healthy group,and no treatment was given in the healthy group.Serum immunoglobulins A,G,E(IgA,IgG,IgE)were detected before and after treatment in each group,serum cytokines[interleukin-4(IL-4),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),interferon-α(IFN-γ)],plasma neurotransmitters[substance P(SP),vasoactive intestinal peptide(VIP)].Results:Before treatment,compared with healthy group,the contents of IgA,IgG,IL-10,IFN-γ and VIP in observation group and control group were decreased,while the contents of IgE,IL-4,TNF-α and SP were increased,with statistical significance(P<0.05).After treatment,compared with before treatment,IgA,IgG,IL-10,IFN-γ and VIP contents in observation group and control group were increased(P<0.05),and observation group was higher than control group(P<0.05),IgE,IL-4 and SP contents in observation group and control group were decreased(P<0.05).The observation group was lower than the control group(P<0.05).Conclusion:Acupoint liquid nitrogen cryotherapy may improve the immune function of the body,regulate the release of cytokines and regulate neuromediators,and thus play a role in the prevention and treatment of bronchial asthma.

关 键 词：穴位液氮冷冻疗法 神经-内分泌-免疫 支气管哮喘 缓解期 肺气虚 冬病夏治 

分 类 号：R246.1[医药卫生—针灸推拿学]