Photo-catalytic Staphylococcus aureus inactivation and biofilm destruction with novel bis-tridentate iridium(Ⅲ) photocatalyst  

作　　者：Shihao Chen Zhishang Zhang Li Wei Zhongxian Fan Yue Li Xuezhi Wang Tongming Feng Huaiyi Huang 

机构地区：[1]The Fourth People’s Hospital of Foshan,Foshan 528000,China [2]School of Pharmaceutical Science(Shenzhen),Shenzhen Campus of Sun Yat-sen University,Shenzhen 518107,China [3]College of Chemistry and Environmental Engineering,Shenzhen University,Shenzhen 518060,China

出　　处：《Chinese Chemical Letters》2023年第11期191-194,共4页中国化学快报（英文版）

基　　金：financially supported by the“Summit Plan”High-Level Hospital Construction Project of Foshan(No.FSSYKF-2020002);the Medical Scientific Research Projects of Foshan Health Bureau(No.20210358);the National Natural Science Foundation of China(NSFC,Nos.22277153,22007104);Guangdong Basic and Applied Basic Research Foundation(No.2021B1515020050);Science,Technology and Innovation Commission of Shenzhen Municipality Project(No.JCYJ20190807152616996);the Fundamental Research Funds for the Central Universities(No.22lgqb37).

摘　　要：Bacterial infection is currently a serious challenge globally, causing death of thousands of human beings. New antimicrobial agents with novel mechanism of action are urgently needed. Transition metal complexes have shown great potentials in photodynamic and photocatalytic therapy. Herein, we take full advantage of metal photocatalyst and successfully developed a novel cyclometalated iridium(Ⅲ) complex(Ir1) with higher biofilm damage efficiency than the clinical antibiotics. Ir1 synergistically generates reactive oxygen species and coenzyme photocatalytic activity with high efficiency under white light irradiation. Combined with these properties, Ir1 exhibited excellent photoinactivation of S. aureus and effectively damaged the biofilm. This work provides a new approach for the development of antibacterial photodynamic therapy.

关 键 词：Ir(Ⅲ)photocatalyst NADH depletion Reactive oxygen species Antimicrobial photocatalytic therapy 

分 类 号：O62[理学—有机化学]