Red/NIR emission carbonized polymer dots based on citric acid-benzoylurea and their application in lymph nodes imaging  

作　　者：Feishi Shan Tingrui Zhang Chengshuang Liao Xue Yue Jing Zhang Li Yan Yanman Liu Zhixing Cao Min Wang Yahui Zhang Leyong Wang Zhouyu Wang Xiaoqi Yu 

机构地区：[1]Sichuan Engineering Research Center for Molecular Targeted Diagnostic&Therapeutic Drugs,Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province,Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City,Department of Chemistry,Xihua University,Chengdu 610039,China [2]State Key Laboratory of Southwestern Chinese Medicine Resources,Pharmacy School,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China [3]State Key Laboratory of Analytical Chemistry for Life Science,Key Laboratory of Mesoscopic Chemistry of MOE,Jiangsu Key Laboratory of Advanced Organic Materials,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China

出　　处：《Chinese Chemical Letters》2023年第11期225-230,共6页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.U21A20308);Sichuan Science and Technology Program(Nos.21ZDYF3218,2022ZYD0048);Talent Project of Sichuan Province,Sichuan Provincial College Student Innovation Training Program(Nos.S202010650073,S202210623049).

摘　　要：Identification of lymph nodes(LNs)is critical for studies of the structure,the role in disease development,and the efficacy of disease treatment.Carbonized polymer dots(CPDs)are expected to be potential LNs-targeted imaging agents due to their excellent properties with special structure,better photoluminescence(PL)and great biocompatibility.Herein,a red/near infrared(NIR)emission CPDs(RCPDs)with one and two-photon bioimaging based on citric acid(CA)and benzoylurea(BU)are prepared.Notably,the RCPDs are capable of targeting LNs for imaging.Lymphocyte homing has been demonstrated to be the cellular mechanism of RCPDs target LNs imaging.This work has developed a new nanomaterial for targeted imaging of LNs,while the biological applications of CPDs have been expanded and deepened.

关 键 词：Carbonized polymer dots Red/NIR emission LNs-targeting Lymphocyte homing 

分 类 号：R52[医药卫生—内科学]