关于婴儿重症百日咳诊断的几点思考  

Some thoughts on the diagnosis of severe pertussis in infants

作　　者：姚开虎 Yao Kaihu(Key Laboratory of Major Diseases in Children,Ministry of Education,National Key Discipline of Pediatrics(Capital Medical University),Laboratory of Microbiology,Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,National Clinical Research Center for Respiratory Disease,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院,北京市儿科研究所微生物研究室,儿科学国家重点学科,儿科重大疾病研究教育部重点实验室,国家呼吸系统疾病临床医学研究中心,北京100045

出　　处：《中华实用儿科临床杂志》2023年第11期845-849,共5页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金(81973100);国家呼吸系统疾病临床医学研究中心呼吸专项(HXZX-202106)。

摘　　要：近年来,百日咳病原学诊断方面虽然取得了很大进展,但治疗仍不能令人满意,尤其是重症百日咳的诊断和治疗亟待规范。迄今尚未见重症百日咳诊断指南,文献报告中使用的诊断名称、定义或诊断标准均存在明显不同,治疗有效性研究之间的差异也难以评估。现围绕重症百日咳诊断问题,针对婴儿百日咳筛查、重症和死亡风险评估、严重度评估及诊断等提出几点个人意见,希望能引起临床对相关问题的重视。In recent years,although great progress has been made in the etiology diagnosis of pertussis,the treatment is unsatisfactory.In particularly,the diagnosis and treatment of severe pertussis urgently need standardization.To date,no diagnostic guidelines for severe pertussis have been published.There are many differences in diagnostic terms,definitions,or diagnostic criteria for severe pertussis in published reports,and it is also difficult to evaluate the efficacy difference among therapeutic strategies for pertussis.This article aims to provide several personal opinions on the diagnosis of severe pertussis,including infant pertussis screening,risk assessment of severe illness and death,severity assessment,and diagnosis,thus highlighting the clinical concern of severe pertussis in infants.

关 键 词：百日咳 重症监护 诊断 婴儿 

分 类 号：R725.1[医药卫生—儿科]