基于肿瘤血管“疏”/“堵”调控的中药抗肿瘤研究进展  

Research progress on anti-tumor effects by traditional Chinese medicine based on "soothing" or "blockage" regulation of tumor vessels

作　　者：付丽 吴淑洋 李敏[1] 吴亿晗 章津铭[1] FU Li;WU Shu-yang;LI Min;WU Yi-han;ZHANG Jin-ming(State Key Laboratory of Southwestern Chinese Medicine Resources,Pharmacy School,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院西南特色中药资源国家重点实验室,四川成都611137

出　　处：《中国中药杂志》2023年第19期5131-5141,共11页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(81973662);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202209)。

摘　　要：调控肿瘤血管已成为目前临床抗肿瘤治疗的常用策略之一。近年来研究发现,常规抑制肿瘤血管新生的“饥饿疗法”,其抗肿瘤治疗效果并不理想,甚至会造成肿瘤微环境的进一步恶化,引起肿瘤耐药、远端转移等,增加了肿瘤转移和复发的风险。然而,适当的采用抗血管生成药物能够促进肿瘤血管正常化,改善肿瘤血管的结构和功能,使肿瘤内功能性血管增多,无效血管减少,有利于促进抗肿瘤药物在肿瘤内的渗透,改善肿瘤缺氧和免疫抑制的微环境,增强抗肿瘤作用。传统中医对肿瘤病因病机的认识历史悠久,在肿瘤治疗方面也积累了丰富的经验,有着显著的临床优势和广阔的应用前景。该文从肿瘤血管的“疏”/“堵”双向调控角度,对两者常用的分子靶点进行梳理,总结了近年来中药单体-单味药-复方(药对)调控肿瘤血管抗肿瘤的研究现状,并对中药复方及活性成分通过调控肿瘤血管联合其他疗法抗肿瘤的研究进行分析整理,以期为中药调控肿瘤血管功能以抗肿瘤的临床应用提供思路。Regulation of tumor vessels has become one of the most common strategies for clinical anti-tumor therapy.In recent years,studies have found that the anti-tumor effect of limotherapy,which routinely inhibits tumor angiogenesis,is not ideal and may even deteriorate the tumor microenvironment,causing tumor resistance and distal metastasis and increasing the risk of tumor metastasis and recurrence.However,the proper use of anti-angiogenic drugs can promote the normalization of tumor vessels,improve the structure and function of tumor vessels,increase the number of functional vessels in the tumor,and reduce the number of ineffective vessels.It is beneficial to promote the penetration of anti-tumor drugs into the tumor,improve the microenvironment of tumor hypoxia and immunosuppression,and enhance the anti-tumor effect.Traditional Chinese medicine(TCM) has a long history of understanding the etiology and pathogenesis of tumors and has accumulated rich experience in tumor treatment,with significant clinical advantages and broad application prospects.In this study,from the perspective of bidirectional "soothing" or "blockage" regulation of tumor vessels,the commonly used molecular targets were sorted out,and the research status of anti-tumor regulation of tumor vessels by monomer-single herb-compound(herb pair) of TCM in recent years was summarized.The research on the anti-tumor effects of TCM compounds and active ingredients by regulating tumor vessels combined with other therapies was analyzed and sorted out,so as to provide ideas for the clinical application of TCM in regulating functions and anti-tumor effects of tumor vessels.

关 键 词：中药 肿瘤 血管调控 联合应用 血管正常化 

分 类 号：R285[医药卫生—中药学]