参麦平喘汤联合固本平喘汤治疗慢性阻塞性肺疾病合并认知功能障碍患者临床研究  

Clinical Study on Shenmai Pingchuan Decoction Combined with Guben Pingchuan Decoction for Patients with Chronic Obstructive Pulmonary Disease Complicated with Cognitive Dysfunction

作　　者：赵青青[1] 陈婧婧[1] 柳桂菊 孙菲 张琴琴 潘炯伟[1] ZHAO Qingqing;CHEN Jingjing;LIU Guiju;SUN Fei;ZHANG Qinqin;PAN Jiongwei(Department of Respiratory Medicine,Lishui People's Hospital,Lishui Zhejiang 323000,China)

机构地区：[1]丽水市人民医院呼吸内科,浙江丽水323000

出　　处：《新中医》2023年第19期73-77,共5页New Chinese Medicine

基　　金：丽水市科技计划项目(2022GYX63)。

摘　　要：目的:观察参麦平喘汤联合固本平喘汤对慢性阻塞性肺疾病(COPD)合并认知功能障碍患者的临床疗效。方法:选取82例COPD合并认知功能障碍患者为研究对象,按随机数字表法分为对照组40例与研究组42例。对照组采用固本平喘汤治疗,研究组在对照组基础上服用参麦平喘汤治疗。比较2组治疗前后肺功能、炎症因子、血气分析指标及认知功能、睡眠质量评分、中医证候积分,并比较2组临床疗效。结果:研究组治疗总有效率88.10%,高于对照组70.00%(P<0.05)。治疗后,2组用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、呼气峰流量(PEF)均升高(P<0.05),且研究组高于对照组(P<0.05)。治疗后,2组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、降钙素原(PCT)水平均降低(P<0.05),且研究组低于对照组(P<0.05)。治疗后,2组动脉二氧化碳分压(PaCO_(2))降低(P<0.05),动脉氧分压(PaO_(2))升高(P<0.05),且研究组PaCO_(2)水平低于对照组(P<0.05),PaO_(2)水平高于对照组(P<0.05)。治疗后,2组简易精神状态检查量表(MMSE)评分均升高(P<0.05),匹茨堡睡眠质量指数量表(PSQI)评分均降低(P<0.05),且研究组MMSE评分高于对照组(P<0.05),PSQI评分低于对照组(P<0.05)。治疗后,2组主症、次症中医证候积分均降低(P<0.05),且研究组低于对照组(P<0.05)。结论:参麦平喘汤联合固本平喘汤治疗COPD合并认知功能障碍患者,可提高肺功能、认知功能,改善炎症因子水平。Objective:To observe the clinical effect of Shenmai Pingchuan Decoction combined with Guben Pingchuan Decoction for patients with chronic obstructive pulmonary disease(COPD) complicated with cognitive dysfunction.Methods:A total of 82 cases of patients with COPD complicated with cognitive dysfunction were selected as the study objects and divided into the control group and the study group according to the random number table method,with 40 and 42 cases in each group respectively.The control group was treated with Guben Pingchuan Decoction,and the study group was additionally treated with Shenmai Pingchuan Decoction based on treatment of the control group.Lung function,inflammatory factors,blood gas analysis indexes,cognitive function,sleep quality scores,and traditional Chinese medicine(TCM) syndrome scores were compared before and after treatment between the two groups,and the clinical effects were compared between the two groups.Results:The total effective rate was 88.10%in the study group,higher than that of 70.00% in the control group(P<0.05).After treatment,forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1)),and peak expiratory flow rate(PEF) in the two groups were increased(P<0.05),and the above indexes in the study group were higher than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and procalcitonin(PCT) in the two groups were decreased(P<0.05),and the above levels in the study group were lower than those in the control group(P<0.05).After treatment,arterial partial pressure of carbon dioxide(PaCO_(2)) levels were decreased(P<0.05),and arterial partial pressure of oxygen(PaO_(2))levels were increased(P<0.05);PaCO_(2)level in the study group was lower than that in the control group(P<0.05),and PaO_(2)level was higher than that in the control group(P<0.05).After treatment,the scores of Mini Mental State Examination Scale(MMSE) in the two groups were increased(P<0.05),and Pittsburgh Sleep Quality Index(PSQI)

关 键 词：慢性阻塞性肺疾病 认知功能障碍 参麦平喘汤 固本平喘汤 肺功能 认知功能 炎症因子 

分 类 号：R563.9[医药卫生—呼吸系统] R749.1[医药卫生—内科学]