督灸疗法对强直性脊柱炎功能改善的临床研究  

Clinical Effect of Du-Moxibustion on Function Improvement of Ankylosing Spondylitis

作　　者：孟姝丽 梁栋 李雪颖 姚梦真 孙铮 MENG Shuli;LIANG Dong;LI Xueying;YAO Mengzhen;SUN Zheng(Feicheng Hospital of Traditional Chinese Medicine,Taian Shandong 271600,China;Shandong First Medical University&Shandong Academy of Medical Sciences,Taian Shandong 271000,China)

机构地区：[1]肥城市中医医院,山东泰安271600 [2]山东第一医科大学(山东省医学科学院),山东泰安271000

出　　处：《新中医》2023年第19期186-191,共6页New Chinese Medicine

基　　金：山东省中医药科技项目课题(E-324);山东省研究生教育质量提升计划立项课题(SDYAL18094);山东省中医药科技发展计划项目课题(2017-251)。

摘　　要：目的:观察督灸疗法对强直性脊柱炎患者关节功能的影响。方法:选取120例强直性脊柱炎患者,按随机数字表法分为干预组及对照组各60例。对照组给予常规治疗护理,干预组在此基础上实施督灸疗法干预。观察2组临床疗效,比较2组干预前、干预后30 d、 90 d、 180 d Bath强直脊柱炎活动指数(BASDAI)、Bath强直脊柱炎功能指数(BASFI)、实验室检查[血沉(ESR)、C-反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)]指标值的变化。结果:干预组临床疗效总有效率为95.0%,对照组为81.7%,2组比较,差异有统计学意义(P<0.05)。2组BASDAI各项目评分采用重复测量方差分析结果显示,四个时间点的BASDAI各项目评分差异具有统计学意义(P<0.05)。2组在干预后30 d、90 d、180 d BASDAI各项目评分比较,差异均具有统计学意义(P<0.05),时间与组别存在交互效应(P<0.05)。2组BASFI指数的时间效应和组间效应差异具有统计学意义(P<0.05);BASFI评分存在时间与组间因素的交互作用(P<0.05),2组功能程度随时间的变化而趋势有所不同,干预组下降趋势大于对照组。2组ESR、CRP、TNF-α三项指标的时间效应和组间效应均有统计学意义(P<0.05),2组TNF-α存在交互作用(P<0.05),ESR、CRP、TNF-α三项指标随治疗干预时间的延长而降低。干预后90 d和180 d三项指标水平差异均具有统计学意义(P<0.05)。结论:在常规治疗基础上进行督灸疗法治疗效果更为显著,可改善关节功能及疾病活动度,增强疗效。Objective:To observe the effect of Du-moxibustion on function improvement of ankylosing spondylitis.Methods:A total of 120 cases of patients with ankylosing spondylitis were selected and divided into the intervention group and the control group according to the random number table method,with60 cases in each group.The control group was treated with routine treatment and nursing,and the intervention group was additionally treated with Du-moxibustion based on the treatment of the control group.The clinical effects were observed in the two groups.Before intervention and after intervention at30,90,and 180 days,the changes in Bath Ankylosing Spondylitis Disease Activity Index(BASDAI),Bath Ankylosing Spondylitis Function Index(BASFI),and laboratory indexes including erythrocyte sedimentation rate(ESR),C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α) were compared between the two groups.Results:The total effective rate was 95.0% in the intervention group,and 81.7% in the control group,the difference being significant(P<0.05).The scores of each BASDAI item were evaluated by the results of repeated measurement analysis of variance,which showed that there was a significant difference being found in the scores of BASDAI at the four time points in the two groups(P<0.05).After intervention at 30,90,and 180 days,the comparison of BASDAI scores between the two groups showed significant differences(P<0.05),and there was an interaction effect between time and group(P<0.05).The time effect and inter group effect differences of the BASFI indexes between the two groups showed significant difference(P<0.05);there is an interaction between time and inter group factors in the BASFI scores(P<0.05),and the trend of function degrees varies between the two groups over time,and the decreasing trend in the intervention group is greater than that in the control group.The time effect and inter-group effect of indexes of ESR,CRP,and TNF-α showed significant differences(P<0.05),and TNF-α in the two groups showed interaction(P<0.05)

关 键 词：强直性脊柱炎 督灸 Bath强直脊柱炎活动指数 Bath强直脊柱炎功能指数 

分 类 号：R259[医药卫生—中西医结合]