阿帕他胺致重症多形红斑1例  

One Case of Stevens-Johnson Syndrome Caused by Apalutamide

作　　者：黄令杰 林山 李金雨[1] HUANG Lingjie;LIN Shan;Li Jinyu(Department of Urology,the 909 th Hospital,Dongnan Hospital of Xiamen University,Zhangzhou,Fujian 363000,China)

机构地区：[1]第九〇九医院、厦门大学附属东南医院泌尿外科,福建漳州363000

出　　处：《药学与临床研究》2023年第5期462-463,共2页Pharmaceutical and Clinical Research

摘　　要：1例70岁男性转移性去势敏感性前列腺癌患者,口服阿帕他胺治疗32天后开始出现全身性红色皮疹伴有局部破溃,继发全身性感染。诊断为重症多形红斑,考虑与阿帕他胺相关。停用该药,予抗炎、抗过敏、抗感染、静滴免疫球蛋白以及对症支持治疗后,患者病情好转。A 70-year-old male patient with metastatic castration-sensitive prostate cancer developed a systemic erythema with local ulceation and gradually developed a systemic infection after 32 days of apalu-tamide treatment.According to the dermatology and pharmacy consultation,the patient was diagnosed as Stevens-Johnson syndrome witch was thought to be related to apalutamide.Apalutamide was stopped and the patient's symptoms improved after anti-inflammatory,anti-allergic,anti-infective,intravenous im-munoglobulin and symptomatic and supportive treatments.

关 键 词：阿帕他胺 重症多形红斑 前列腺癌 不良反应 

分 类 号：R969.3[医药卫生—药理学]