Epidemiology of co-infections in pregnant women living with human immunodeficiency virus 1 in rural Gabon:a cross-sectional study  

作　　者：Saskia Dede Davi Dearie Glory Okwu Marc Luetgehetmann Frederique Mbang Abba Martin Aepfelbacher Lillian Rene Endamne Ayodele Alabi Rella Zoleko-Manego Ghyslain Mombo-Ngoma Saidou Mahmoudou Marylyn Martina Addo Michael Ramharter Johannes Mischlinger 

机构地区：[1]Centre of Tropical Medicine,Bernhard-Nocht Institute for Tropical Medicine and I.Department of Medicine,University Medical Center Hamburg-Eppendorf,Hamburg,Germany [2]German Centre for Infection Research,Partner Site Hamburg-Lübeck-Borstel-Riems,Hamburg-Lübeck-Borstel-Riems,Hamburg,Germany [3]Centre de Recherches Médicales de Lambaréné,Lambaréné,Gabon Saskia Dede Davi,Dearie Glory Okwu,Frederique Mbang Abba,Ayodele [4]Center for Diagnostics,Institute of Medical Microbiology,Virology and Hygiene,University Medical Center Hamburg-Eppendorf(UKE),Hamburg,Germany [5]Albert-Schweitzer Hospital,Lambaréné,Gabon [6]Department of Parasitology,Leiden University Medical Center,Albinusdreef,The Netherlands [7]Department for Clinical Immunology of Infectious Diseases and I.Department of Medicine,University Medical Center Hamburg-Eppendorf,Hamburg,Germany

出　　处：《Infectious Diseases of Poverty》2023年第4期83-92,共10页贫困所致传染病（英文）

基　　金：Open Access funding enabled and organized by Projekt DEAL.This work was supported by the German Centre for Infection Research and the German Agency for International Cooperation GmbH.The funders had no role in the study design,decision to publish the study protocol or preparation of the manuscript.

摘　　要：Background There is no recent epidemiological data on HIV infection in Gabon,particularly in pregnant women.To close this gap,an HIV-prevalence survey was conducted among Gabonese pregnant women,followed by a cross-sectional case-control study in which the prevalence of various co-infections was compared between HIV-positive and HIV-negative pregnant women.Methods Between 2018 and 2019,data for the HIV-prevalence survey were collected retrospectively in 21 Gabonese antenatal care centres(ANCs).Subsequently,for the prospective co-infection study,all HIV-positive pregnant women were recruited who frequented the ANC in Lambarénéand a comparator sub-sample of HIV-negative pregnant women was recruited;these activities were performed from February 2019 to February 2020.The mean number of coinfections was ascertained and compared between HIV-positive and HIV-negative women.Additionally,the odds for being co-infected with at least one co-infection was evaluated and compared between HIV-positive and HIV-negative women.Results HIV-positivity was 3.9%(646/16,417)among pregnant women.183 pregnant women were recruited in the co-infection study.63%of HIV-positive and 75%of HIV-negative pregnant women had at least one co-infection.There was a trend indicating that HIV-negative women were more often co-infected with sexually transmitted infections(STIs)than HIV-positive women[mean(standard deviation,SD):2.59(1.04)vs 2.16(1.35),respectively;P=0.056];this was not the case for vector-borne infections[mean(SD):0.47(0.72)vs 0.43(0.63),respectively;P=0.59].Conclusions Counterintuitively,the crude odds for concomitant STIs was lower in HIV-positive than in HIV-negative women.The change of magnitude from the crude to adjustedOR is indicative for a differential sexual risk factor profile among HIV-positive and HIV-negative women in this population.This might potentially be explained by the availability of sexual health care counselling for HIV-positive women within the framework of the national HIV control programme,while no such simil

关 键 词：HIV Cross-sectional study PREGNANCY Sexually transmitted infections GABON 

分 类 号：R714.251[医药卫生—妇产科学]