A Versatile,Electrophilic Reagent for Monofluoromethylthiolation  

作　　者：Rui Wang Long Lu Qilong Shen 

机构地区：[1]Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,ChineseAcademyof Sciences,345 Lingling Road,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2023年第18期2317-2329,共13页中国化学（英文版）

基　　金：the financial support from the National Key Research and Development Program of China(No.2021YFF0701700).

摘　　要：Comprehensive Summary,A new electrophilic monofluoromethylthiolating reagent N-fluoromethylthiophthalimide PhthSCH2F 1 was developed.Reagent 1 could be readily synthesized from easily available starting materials benzyl mercaptan and CH_(2)FCl in three steps.N-Fluoromethylthiophthalimide 1 is a powerful electrophilic monofluoromethylthiolating reagent that allows the monofluoromethylthiolation of a wide range of nucleophiles including alkynes,aryl/vinyl boronic acids,electron-rich heteroarenes,β-ketoesters and oxindoles,as well as thiols under mild conditions.

关 键 词：FLUORINE Monofluoromethylthiolation ELECTROPHILIC SULFUR 

分 类 号：O62[理学—有机化学]