miR-26b、miR-1233-3p、miR-206与妊娠期高血压血管内皮功能关系及三者联合预测HDCP不良妊娠结局的ROC曲线分析  

Relationship Between miR-26b,miR-1233-3p,miR-206 and Vascular Endothelial Function in Gestational Hypertension and ROC Curve Analysis of the Combination of the Three in Predicting the HDCP Adverse Pregnancy Outcomes

作　　者：郭永平[1] 周东芳[2] 杨亚莉[1] 马颖[1] GUOYongping;ZHOU Dongfang;YANG Yali;MA Ying(Department of Obstetrics,Baoji Maternal and Child Health Hospital,Baoji Shaanci 721000,China)

机构地区：[1]宝鸡市妇幼保健院产科,陕西宝鸡721000 [2]宝鸡市妇幼保健院检验科,陕西宝鸡721000

出　　处：《联勤军事医学》2023年第9期743-747,共5页Military Medicine of Joint Logistics

基　　金：陕西省2021年科技计划项目(2021SF211)。

摘　　要：目的 探讨微小RNA-26b(microRNA-26b, miR-26b)、miR-1233-3p、miR-206与妊娠期高血压(hypertensive disorders complicating pregnancy, HDCP)血管内皮功能关系及三者联合预测HDCP不良妊娠结局的价值。方法 选取2019-04/2021-04月作者医院收治的104例HDCP患者的病历资料进行分析。根据是否发生不良妊娠结局分为发生组(n=25)和未发生组(n=79)。比较两组基线资料、肱动脉内皮依赖性舒张功能(flow mediated dilation, FMD)、miR-26b、miR-1233-3p、miR-206。应用Pearson相关分析探讨miR-26b、miR-1233-3p、miR-206与FMD关系。采用多因素Logistic回归分析探讨不良妊娠结局的相关影响因素。采用受试者工作特征(receiver operating characteristic, ROC)曲线及曲线下面积(area under the curve, AUC)分析miR-26b、miR-1233-3p、miR-206预测HDCP不良妊娠结局的价值。结果 发生组患者病情阶段与未发生组比较,差异有统计学意义(P<0.05)。发生组患者FMD、miR-206低于未发生组,miR-26b、miR-1233-3p高于未发生组(P均<0.05)。miR-26b、miR-1233-3p与FMD呈负相关(r=-0.538、-0.588,P均<0.001),miR-206与FMD呈正相关(r=0.653,P<0.001)。调整病情阶段、FMD后,miR-26b、miR-1233-3p、miR-206仍与HDCP不良妊娠结局相关(P<0.05)。miR-26b、miR-1233-3p、miR-206及三者联合预测HDCP不良妊娠结局的AUC分别为0.771(95%CI:0.658~0.884)、0.790(95%CI:0.673~0.907)、0.772(95%CI:0.678~0.856)、0.840(95%CI:0.743~0.936),三者联合预测价值最大。结论 miR-26b、miR-1233-3p、miR-206与HDCP血管内皮功能、不良妊娠结局有关,三者联合检测可作为HDCP不良妊娠结局的一个有效预测方案。Objective To investigate the relationship between microRNA-26b(miR-26b), miR-1233-3p, miR-206 and vascular endothelial function in hypertensive disorders complicating pregnancy(HDCP), and the value of the combination of the three in predicting HDCP adverse pregnancy outcomes. Methods The medical records of 104 HDCP patients admitted to the author′s hospital from April 2019 to April 2021 were selected for analysis. According to whether adverse pregnancy outcomes had occurred, the patients were divided into the occurrence group(n=25) and the non-occurrence group(n=79). Baseline data, flow mediated dilation(FMD), miR-26b, miR-1233-3p and miR-206 were compared between the two groups. The relationship between miR-26b, miR-1233-3p, miR-206 and FMD was explored by Pearson correlation analysis. The relevant influencing factors of adverse pregnancy outcomes were analyzed by Multivariate Logistic regression. The value of miR-26b, miR-1233-3p and miR-206 in predicting HDCP adverse pregnancy outcomes was analyzed by the receiver operating characteristic(ROC) curve and area under the curve(AUC). Results The disease stages of the patients in occurrence group were compared with the non-occurrence group, and the difference was statistically significant(P<0.05);FMD and miR-206 in patients in the occurrence group were lower than those of the non-occurrence group, and miR-26b and miR-1233-3p were higher than those of the non-occurrence group(all P<0.05). miR-26b, miR-1233-3p were negatively correlated with FMD(r=-0.538,-0.588, all P<0.001), miR-206 was positively correlated with FMD(r=0.653, P<0.001). After adjusting the disease stage and FMD, miR-26b, miR-1233-3p, miR-206 were still associated with HDCP adverse pregnancy outcomes(P<0.05). The AUC of miR-26b, miR-1233-3p, miR-206 and their combination in predicting HDCP adverse pregnancy outcomes was 0.771(95%CI: 0.658-0.884), 0.790(95%CI: 0.673-0.907), 0.772(95%CI: 0.678-0.856) and0.840(95%CI: 0.743-0.936) respectively, the combination of the three had the greatest effects. Conc

关 键 词：microRNA-26b miR-1233-3p miR-206 妊娠期高血压 血管内皮功能 不良妊娠结局 

分 类 号：R714.246[医药卫生—妇产科学]