孕周不符的胎儿发育与孕妇血糖、血脂和促甲状腺激素异常相关性研究  

A study on correlation between fetal development that does not match gestational age and abnormal blood glucose,blood lipids,and thyroid stimulating hormone levels in pregnant women

作　　者：李海朋[1] 闫丽纬 康欣[1] 云丽媛 董亚男[1] LI Haipeng;YAN Liwei;KANG Xin;YUN Liyuan;DONG Yanan(Tangshan Xiehe Hospital,Tangshan 063000,China)

机构地区：[1]河北省唐山市协和医院,063000

出　　处：《中国煤炭工业医学杂志》2023年第5期513-516,共4页Chinese Journal of Coal Industry Medicine

基　　金：河北省医学科学研究课题计划(编号:20221832)。

摘　　要：目的本研究通过观测孕中期胎儿体重与孕妇血糖、血脂的关系;孕中期彩超检测胎儿骨骼发育异常与孕妇甲状腺激素水平的相关性,探讨激素水平的变化对胎儿生长发育的影响。方法选取2018年12月—2021年12月在唐山市协和医院进行就诊的妊娠患者,对符合入排标准的患者按照临床表现将其分为观察组,即胎儿体重大于相应孕周的孕妇或伴有胎儿骨骼发育迟缓的的孕妇;对照组,即胎儿体重与相应孕周一致的孕妇或胎儿骨骼发育无异常的孕妇。检测孕妇血糖、血脂和促甲状腺激素的含量、脐动脉血流S/D比值并测量体重。收集新生儿身长和体重,胎儿体重、股骨和肱骨长度数据。比较分析观察组与对照组的孕妇参数。结果孕妇的甲状腺功能指标TSH、空腹血糖和服糖2h后的血糖、血脂水平、S/D比值在二组间存在差异。此外二组间糖耐量发生率差异有统计学意义。S/D比值与血清TSH呈正相关。观察组与对照组相比,胎儿股骨长度及肱骨长度和体重、新生儿身长及体重差异也有统计学意义。结论妊娠中期彩超发现胎儿体重过大,结合孕妇血糖、血脂水平的检查,可以更好的对妊娠中期胎儿体重状况进行了解和评估。妊娠中期彩超发现胎儿骨骼发育异常,结合孕妇TSH水平的检查,可以更好的对胎儿骨骼发育状况进行了解和评估。Objective In this study,the relationship between fetal weight and maternal blood glucose and blood lipids in the second trimester was observed,the correlation between fetal skeletal retardation and thyroid hormone levels in pregnant women was detected by color ultrasound in the second trimester,and the effects of changes in hormone levels on fetal growth and development were explored by congenital fetal nervous system malformations.Methods Pregnant patients who visited Tangshan Xiehe Hospital from December 2018 to December 2021 were selected,and the patients who met the admission criteria were divided into observation groups according to their clinical manifestations,that is,pregnant women with fetal weight greater than the corresponding gestational age or pregnant women with fetal skeletal retardation.Control group,that is,pregnant women whose fetal weight is consistent with the corresponding gestational age or pregnant women who have no skeletal development of the fetus.Measure blood sugar,lipids,and thyroid-stimulating hormone levels in pregnant women and measure weight.Collect data on neonatal length and weight,fetal weight,femur and humerus length.Maternal parameters of the observation group and the control group were compared and analyzed.Results There were differences in thyroid function indicators TSH,fasting blood glucose,blood glucose and blood glucose and lipid levels after taking sugar for 2 hours between experiment group and control group.In addition,there was a statistically significant difference in the occurrence of glucose tolerance between the two groups.The S/D ratio was positively correlated with serum TSH.Compared with the control group,there were also significant differences in fetal fetal femur length,humerus length and weight,neonatal length and weight.Conclusion The fetal weight is found in the second trimester color ultrasound,and the fetal weight status can be better understood and evaluated by combining the examination of blood glucose and blood lipid level of pregnant women.The second

关 键 词：TSH 血糖 血脂 胎儿发育 S/D比值 

分 类 号：R71[医药卫生—妇产科学]