PCGF3分子功能及其在疾病中的作用  

Research Progress of PCGF3's Molecular Function and Its Related Diseases

作　　者：尹琦 沈涛 YIN Qi;SHEN Tao(Medicine School,Kunming University of Science and Technology,Kunming,650093;Kunming University of Science and Technology Affiliated Hospital,The First People's Hospital of Yunnan Province,Kunming,650032)

机构地区：[1]昆明理工大学医学院,昆明650093 [2]昆明理工大学附属医院,云南省第一人民医院,昆明650032

出　　处：《基因组学与应用生物学》2023年第9期895-902,共8页Genomics and Applied Biology

基　　金：国家自然科学基金项目(82160384);云南省科技厅科技计划项目(2019FA030,202002AG070062);云南省卫生科技计划项目(L-2019003,2018NS260)共同资助。

摘　　要：多梳家族环指蛋白3(polycomb group ring finger 3,PCGF3)作为PCGF1-6的同源物,也是PCGF3-PRC1复合物的主要组成部分,该复合物具有特定的基因组定位和催化活性,可介导表观遗传组蛋白修饰,并在整个发育过程中维持包括Hox基因在内的许多基因的转录抑制状态。已有研究发现PCGF3与多种疾病的药物疗效、诊断和进展等有关。本文介绍PCGF3及其复合物的结构,阐述PCGF3对染色体结构、X染色体沉默及基因转录的影响和可能机制,并对PCGF3在多种疾病中的作用的相关研究进展进行综述。PCGF3(polycomb group ring ginger 3)as a homologous of the PCGF1-6 and a major component of the PCGF3-PRC1 complex,has a specific genomic localization and catalytic activity.PCGF3 mediates epigenetic histone modifications and maintains transcriptional inhibition of many genes,including Hox gene,throughout organic development.Previous studies have found that PCGF3 is related to the drug efficacy,diagnosis,and progression of multiple diseases.This review first introduces the structure of PCGF3 and its complex,then expounds the influence and possible mechanisms of PCGF3 on chromosome structure,X chromosome silencing and gene transcription.Furthermore,the related research progress of PCGF3 functions in diseases is introduced in this review.

关 键 词：多梳家族环指蛋白3 PCGF3-PRC1 Polycomb家族 疾病 

分 类 号：R341[医药卫生—基础医学]