肿瘤免疫代谢靶向治疗的研究进展  

Research progress of tumor immuno-metabolism-targeted therapy

作　　者：夏睿雪 雷绘敏 周斌兵 朱亮[1,3] XIA Rui-xue;LEI Hui-min;ZHOU Bin-bing;ZHU Liang(Department of Pharmacology and Chemical Biology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Pediatric Translational Medicine Institute Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Shanghai Collaborative Innovation Center for Translational Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院药理学与化学生物学系,上海200025 [2]上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所,上海200127 [3]教育部-省部共建上海市生物医药临床研究与转化协同创新中心/上海市转化医学协同创新中心,上海200025

出　　处：《现代免疫学》2023年第5期417-422,共6页Current Immunology

基　　金：国家自然科学基金面上项目(81872882);国家自然科学基金青年项目(82003772);上海市自然科学基金(21ZR1436700)。

摘　　要：肿瘤免疫疗法的出现改变了许多肿瘤的治疗格局,是肿瘤治疗领域的重大突破。虽然其在一些肿瘤类型中显示出良好疗效,然而,总体反应率仍然偏低,因此需要开发新型的免疫治疗药物及治疗策略。代谢重编程是肿瘤细胞的一大特征,肿瘤微环境中免疫代谢的复杂性是影响肿瘤免疫治疗疗效的重要因素。近年来的研究表明,靶向免疫代谢可以减少免疫抑制,增强抗肿瘤免疫,提高现有肿瘤免疫疗法的疗效甚至克服耐药。文章综述了靶向肿瘤免疫代谢途径治疗的最新进展,包括靶向糖代谢、氨基酸代谢、核苷酸代谢和脂质代谢等,为开发免疫代谢靶向治疗潜力,寻找新靶点提供新思路。The establishment of immunotherapy is a major breakthrough in the field of tumor therapy which has changed its landscape.Although immunotherapy is effective in some tumor types,the overall response rate is still low.Therefore,the development of new immunotherapy drugs and treatment strategies is needed.Metabolic reprogramming is a main characteristic of tumors,and the complexity of immuno-metabolism in tumor microenvironment is probably an important factor affecting the efficacy of tumor immunotherapy.Recent studies have proved that targeting immuno-metabolism may relieve immunosuppression,enhance anti-tumor immunity,improve the efficacy of current tumor immunotherapy,and even overcome drug resistance.This article reviews the latest progress in tumor immuno-metabolism-targeted therapies,including targeting glucose metabolism,amino acid metabolism,nucleotide metabolism,and lipid metabolism.This review will provide ideas for developing new targets for immuno-metabolism-targeted therapies.

关 键 词：免疫治疗 免疫代谢 免疫代谢靶向治疗 

分 类 号：R392.5[医药卫生—免疫学]