常规超声检测骨龄及鉴别性早熟与乳房过早发育  

Conventional ultrasound for evaluation on bone age and differential diagnosis of precocious puberty and premature thelarche

作　　者：冯杰 詹娜萍 肖金霞 冯益炎 蔡斌彬 曾祯 张超[3] FENG Jie;ZHAN Naping;XIAO Jinxia;FENG Yiyan;CAI Binbin;ZENG Zhen;ZHANG Chao(Department of Ultrasound Imaging,Haicang Hospital,Xiamen Medical College,Xiamen 361026,China;Department of Pediatrics,Haicang Hospital,Xiamen Medical College,Xiamen 361026,China;Department of Ultrasound Imaging,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]厦门医学院附属海沧医院超声影像科,福建厦门361026 [2]厦门医学院附属海沧医院儿科,福建厦门361026 [3]华中科技大学同济医学院附属同济医院超声影像科,湖北武汉430030

出　　处：《中国医学影像技术》2023年第11期1702-1705,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察常规超声检测骨龄的可行性及其鉴别特发性中枢性性早熟(ICPP)与乳房过早发育(PT)的价值。方法前瞻性纳入139名儿童,于1周内完成超声骨龄评估和左手及腕部X线检查,分别针对后者以Greulich-Pyle(GP)图谱法和Tanner-Whitehouse 3(TW3)法评估骨龄,评价超声与GP结果的相关性;比较超声与TW3骨龄差、GP与TW3骨龄差之间的差异,观察以超声骨龄鉴别ICPP与PT的价值。结果超声评估骨龄与TW3法结果呈高度正相关(全组:r=0.96;男性r=0.97;女性r=0.96)。超声骨龄与TW3骨龄之差为(-0.3±0.7)岁,GP骨龄与TW3骨龄之差为(-0.2±1.1)岁,其间差异无统计学意义(P>0.05)。ICPP患儿(n=9)超声骨龄与实际年龄差明显大于PT(n=10)患儿[(1.3±1.0)岁vs.(0.2±0.9)岁,(P<0.05)]。结论常规超声可用于测量骨龄,并对鉴别诊断ICPP与PT具有一定价值。Objective To explore the feasibility of conventional ultrasound for evaluation on bone age and differential diagnosis of idiopathic central precocious puberty(ICPP)and premature thelarche(PT).Methods Totally 139 children were prospectively enrolled.Ultrasonic evaluation of bone age was performed.X-ray films of left hand and wrist were acquired within 1 week,and bone age was evaluated using Tanner-Whitehouse 3(TW3)and Greulich-Pyle(GP)atlas method,respectively.The correlation between ultrasound and TW3 bone age was evaluation.The difference of bone age between ultrasound and TW3,between GP and TW3 were compared,and the value of ultrasound in differentiating ICPP from PT was explored.Results There was high correlation between ultrasound and TW3 bone age(whole group:r=0.96;male:r=0.97;female:r=0.96).The difference between ultrasound and TW3 bone age was(-0.3±0.7)years,between GP and TW3 bone age was(-0.2±1.1)years,with no significant difference(P>0.05).The difference between chronological age and ultrasound bone age in children with ICPP(n=9)was significantly greater than that in children with PT(n=10)([1.3±1.0]years vs.[0.2±0.9]years,P<0.05).Conclusion Conventional ultrasound could be used to measure bone age,which was also valuable for differential diagnosis of ICPP and PT.

关 键 词：年龄测定 骨骼 青春期 早熟 超声检查 前瞻性研究 

分 类 号：R725.8[医药卫生—儿科] R445.1[医药卫生—临床医学]