依折麦布辅助常规调脂治疗对肥胖型老年脑梗死患者的影响观察  

Effect of Ezetimibe Assisted Conventional Lipid-regulating Therapy on Elderly Obese Patients with Cerebral Infarction

作　　者：王秋菊 Wang Qiu-ju(Zhengzhou Ninth People's Hospital,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州市第九人民医院,河南郑州450002

出　　处：《罕少疾病杂志》2023年第11期18-19,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的观察依折麦布辅助常规调脂治疗对肥胖型老年脑梗死患者神经功能、调脂效果及血清相关脂肪因子水平的影响。方法选择2017年4月至2019年4月我院就诊的115例肥胖型老年脑梗死患者,根据简单随机法分为观察组61例和对照组54例,其中对照组给予常规调脂治疗,观察组在以上基础给予依折麦布。两组均持续治疗4周。观察两组神经功能、血脂及脂肪因子的差异。结果治疗前两组美国国立卫生研究院卒中量表(NIHSS)评分、脂肪因子比较无明显差异(P>0.05),治疗后均改善(P<0.05),且观察组改善程度高于对照组(P<0.05);治疗后两组趋化素、丝氨酸蛋白酶抑制剂及脂肪素均改善(P<0.05),且观察组改善程度优于对照组(P<0.05)。结论依折麦布辅助基础治疗肥胖型老年脑梗死患者,临床效果显著,不仅能改善患者神经功能,还具有较好调脂效果,对于改善其相关脂肪因子水平也具有明显优势。Objective To observe the effect of ezetimibe assisted conventional lipid-regulating therapy on neurological function,lipid-regulating effect and serum levels of related adipokines in elderly obese patients with cerebral infarction.Methods A study from April 2017 to April 2019 was conducted.One hundred and fifteen patients with cerebral infarction were selected and randomly grouped into observation group(61 cases)and control group(54 cases).The control group was given conventional lipid-regulating therapy.On this basis,the observation group was treated with ezetimibe.Both groups underwent 4 weeks of continuous treatment.The differences in neurological function,blood lipids and serum adipokines between groups were observed.Results The National Institutes of Health Stroke Scale(NI HSS)scores and the levels of triacylglycerol(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)in the two groups were similar before treatment(P>0.05).These indicators were all improved after treatment(P<0.05),and the improvements in observation group were greater as compared with control group(P<0.05).Chemokine,serpin and adipokine were improved after treatment(P<0.05),and the improvement in observation group were greater(P<0.05).Conclusion The clinical effect of ezetimibe assisted conventional lipid-regulating therapy on elderly obese patients with cerebral infarction is significant.It can not only improve neurological function but also has good lipid-regulating effect.It also has significant advantages in improving the levels of serum related adipokines.

关 键 词：依折麦布 辅助治疗 肥胖型老年脑梗死 神经功能 调脂效果 血清脂肪因子 

分 类 号：R45[医药卫生—治疗学]