术前血小板参数对围术期神经认知障碍的预测研究  

The Predictive Study of Preoperative Platelet Parameters for Perioperative Neurocognitive Disorders

作　　者：杨木强[1] 麻黎斯 张洪军[1] 葛军甫 司建洛[1] YANG Mu-qiang;MA Li-si;ZHANG Hong-jun;GE Jun-fu;SI Jian-luo(Department of Anesthesiology,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,Henan Province,China)

机构地区：[1]河南科技大学第一附属医院麻醉科,河南洛阳471003

出　　处：《罕少疾病杂志》2023年第11期23-24,27,共3页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技计划项目资助(LHGJ20210605)。

摘　　要：目的探讨术前血小板参数对围术期神经认知障碍(PND)的预测价值。方法选择2017年1月至2022年9月在河南科技大学第一附属医院接受TURP手术且术后发生PND的36例患者纳入病例组。按照1:2进行条件配对,随机选取同期行TURP手术但未发生PND的患者72例作为对照组。采集患者的一般资料和术前血小板参数,统计分析TURP手术患者发生围术期PND的危险因素,并进行ROC曲线评估预测价值。结果术中出血量、镇痛泵是否使用、术前血小板平均体积(MPV)和血小板分布宽度(PDW)与TURP患者术后PND的发生密切相关(P<0.05);logistics回归分析显示:MPV和PDW是老年患者TURP术后PND的独立危险因素(P<0.05);MPV和PDW呈正相关,对PND的发生有预测价值(P<0.05)。结论MPV和PDW对TURP患者术后的PND有一定的预测价值。Objective To explore the predictive value of preoperative platelet parameters in perioperative neurocognitive impairment(PND).Methods 36 patients with postoperative PND who underwent TURP operation in the first affiliated Hospital of Henan University of Science and Technology from January 2017 to September 2022 were selected into the case group.According to 1:2 condition matching,72 patients who underwent TURP without PND were randomly selected as the control group.The general data of patients and preoperative platelet parameters were collected to statistically analyze the risk factors of perioperative PND in patients undergoing TURP,and the predictive value of ROC curve was evaluated.Results The amount of intraoperative blood loss,the use of analgesic pump,preoperative mean platelet volume(MPV)and platelet distribution width(PDW)were closely related to the occurrence of postoperative PND in TURP patients.Logistics regression analysis showed that MPV and PDW were independent risk factors of PND in elderly patients after TURP.There was a positive correlation between MPV and PDW,which could predict the occurrence of PND.Conclusion MPV and PDW can predict the PND of patients with TURP after operation.

关 键 词：围术期神经认知障碍 血小板参数 预测 

分 类 号：R691.2[医药卫生—泌尿科学] R749.5[医药卫生—外科学]