地塞米松联合免疫球蛋白干预初诊ITP患儿的疗效及其对BAFF、IL-10、TGF-β1水平的影响  

Efficacy of Dexamethasone Combined with Immunoglobulin Intervention on Children with Newly Diagnosed ITP and Its Influence on BAFF,IL-10 and TGF-β1 Levels

作　　者：陈海榅 许凯丽 石水玲 黄园桃 Chen Hai-wen;Xu Kai-li;Shi Shui-ling;Huang Yuan-tao(Department of Pediatrics,Longyan First Hospital,Longyan 364000,Fujian Province,China)

机构地区：[1]福建省龙岩市第一医院儿科,福建龙岩364000

出　　处：《罕少疾病杂志》2023年第11期98-99,102,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的对初诊原发免疫性血小板减少症(ITP)患儿采用地塞米松联合免疫球蛋白干预观察其疗效,并探究其对关于B细胞活化因子(BAFF)、关于白细胞介素-10(IL-10)以及关于转化生长因子-β1(TGF-β1)水平的影响。方法选取我院收治的100例初诊ITP患儿,时间为2019年6月至2022年6月作为研究对象,根据随机分组法分为对照组与观察组各50例,对照组治疗方式为地塞米松治疗,观察组治疗方式为地塞米松联合免疫球蛋白治疗,观察两组初诊ITP患儿的疗效效果,比较两组关于血小板参数指标、血清学指标、临床相关指标以及关于不良发应发生率。结果观察组疗效优于对照组,差异有统计学意义(P<0.05);治疗后观察组血小板相关参数显著优于对照组,差异显著(P<0.05);治疗后,观察组关于BAFF、以及关于TGF-β1水平显著低于对照组,观察组关于IL-10水平显著高于对照组,差异显著(P<0.05);观察组关于临床指标时间中一是血小板升高、二是血小板恢复正常以及出血控制时间与对照组相比均显著缩短,差异显著(P<0.05)。结论地塞米松联合免疫球蛋白干预初诊ITP患儿临床效果更优,有效改善患儿血清学指标、血小板参数指标以及临床指标,值得在临床上进行推广。Objective To observe the efficacy of dexamethasone combined with immunoglobulin intervention on newly diagnosed primary immune thrombocytopenia(ITP)in children,and to explore its influence on the levels of BAFF,interleukin-10(IL-10)and transforming growth factor-β1(TGF-β1).Methods 100 children with newly diagnosed ITP were enrolled between June 2019 and June 2022,and they were randomly classified into control group(50 cases)and observation group(50 cases).The control group received dexamethasone treatment,while the observation group was given dexamethasone combined with immunoglobulin therapy.The therapeutic effect was observed,and the platelet parameters,serological indicators,clinical related indicators and incidence rates of adverse reactions were compared.Results Compared with control group,the efficacy was better in observation group(P<0.05).The platelet-related parameters after treatment were obviously better than control group(P<0.05).After treatment,the BAFF and TGF-β1 levels were distinctly lower while the IL-10 level was significantly higher compared to control group(P<0.05).In terms of clinical indicators,the observation group showed significantly shorter platelet elevation time,normal platelet recovery time and bleeding control time(P<0.05).Conclusion The combination of dexamethasone and immunoglobulin intervention has a better clinical effect on newly diagnosed ITP children,and can effectively improving the serological indicators,platelet parameters,and clinical indicators.

关 键 词：原发免疫性血小板减少症 地塞米松 免疫球蛋白 B细胞活化因子 白细胞介素-10 转化生长因子-β1 

分 类 号：R558.2[医药卫生—血液循环系统疾病]