禾零润肤霜辅助治疗儿童轻度特应性皮炎的临床疗效观察  

Auxiliary effects of Heling emollient in children with mild atopic dermatitis

作　　者：陈立新[1] 王莹[1] 管志伟 任敏 刘欣欣 李钦峰 CHEN Li-xin;WANG Ying;GUAN Zhi-wei(Department of Dermatology,Tianjin Children's Hospital,Tianjin 300074,China)

机构地区：[1]天津大学儿童医院、天津市儿童医院皮肤科,天津300074

出　　处：《中国实用儿科杂志》2023年第11期869-872,共4页Chinese Journal of Practical Pediatrics

基　　金：天津市卫生健康委员会科技项目(ZC20062)。

摘　　要：目的探讨外用禾零润肤霜对儿童轻度特应性皮炎(atopic dermatitis,AD)的辅助治疗作用。方法采用自身对照的研究设计,收集2022年11月至2023年3月就诊于天津市儿童医院皮肤科门诊的AD患儿90例,入组0.5~12.0岁轻度AD患儿,试验部位每天外用受试保湿润肤霜(禾零润肤霜)2次治疗,分别在入组第1天(D0),第14天(D14)进行症状严重程度评估、皮肤无创参数测试及皮肤微生物取样。结果共入组轻度AD患儿90例,实际完成76例,治疗14 d后两组患儿特应性皮炎评估(SCORAD)评分、PP-NRS瘙痒程度评分较治疗前均降低,且差异有统计学意义(P<0.05);试验部位pH值及角质层含水量较治疗前改善,差异有统计学意义(P<0.05);皮损区菌群分布明显改善,菌群多样性增加,差异有统计学意义(P<0.05),皮损区金黄色葡萄球菌比例降低,其他菌群丰度较治疗前明显增加。结论保湿润肤霜可有效缓解儿童轻度AD的临床症状,修复皮肤屏障,有辅助治疗功效。Objective To observe the auxiliary role of topical emollient in children with mild atopic dermatitis(AD).Methods Using a self-controlled and study design,90 children aged 0.5~12 years with mild AD attending Department of Dermatology,Tianjin Children′s Hospital form Novemher 2022 to March 2023 were enrolled.The tested site was given emollient Heling twice a day,symptom severity assessment,non-invasive skin parameter testing,and skin microbial sampling were conducted on the first day(D0)and the 14th day(D14)of enrollment,respectively.Results Totally 90 children aged 0.5~12 years with mild AD were enrolled in the study,and 76 children who were followed up were included in the analysis.After 14 days of treatment,the SCORAD score and PP-NRS itching score of the two groups decreased compared to before treatment,and the difference was statistically significant(P<0.05);the pH value and stratum corneum water content of the tested site improved significantly compared to before treatment(P<0.05);the distribution of bacterial communities in the lesion area significantly improved,and the diversity of bacterial communities increased,with statistically significant differences(P<0.05).The proportion of Staphylococcus aureus in the lesion area decreased,while the abundance of other bacterial communities significantly increased compared to before treatment.Conclusion In children with mild AD,Heling emollients,as an auxiliary therapy,can effectively alleviate the clinical symptoms,and help to repair the skin barrier.

关 键 词：润肤霜 儿童 特应性皮炎 皮肤屏障 

分 类 号：R72[医药卫生—儿科]