复合羟考酮时环泊酚用于无痛人工流产术的半数有效剂量  

Median effective dose of ciprofol combined with oxycodone in painless abortion surgery

作　　者：王静[1] 李荣华 祝平[1] 蔡靓羽[1] 尹卫娟[1] WANG Jing;LI Ronghua;ZHU Ping;CAI Liangyu;YIN Weijuan(Department of Anesthesiology,Wuxi Hospital of traditional Chinese Medicine,Wuxi 214000,China)

机构地区：[1]无锡市中医医院麻醉科,214000

出　　处：《临床麻醉学杂志》2023年第10期1060-1063,共4页Journal of Clinical Anesthesiology

基　　金：江苏省中医药管理局科技项目(MS2022057)。

摘　　要：目的探讨复合羟考酮时环泊酚用于无痛人工流产术的半数有效剂量(ED_(50))。方法选择择期行无痛人工流产术患者23例,年龄22~40岁,BMI 20~30 kg/m^(2),ASAⅠ或Ⅱ级。麻醉诱导前静脉推注羟考酮008 mg/kg,环泊酚剂量采用序贯法。第1例患者环泊酚剂量为06 mg/kg,阳性反应定义为术中发生体动反应,若出现阳性反应则升高一个剂量等级,相邻剂量相差为005 mg/kg,若出现阴性反应则降低一个剂量等级,直至出现第7个拐点终止研究。计算复合羟考酮时环泊酚用于无痛人工流产术的ED_(50)和95%有效剂量(ED_(95))及其95%可信区间(CI)。根据术中是否发生体动将患者分为两组:阳性组和阴性组。记录睫毛反射消失时间、手术时间、苏醒时间。记录术中恶心、呕吐、注射痛、呼吸抑制、过敏的发生情况。结果复合羟考酮时环泊酚用于无痛人工流产术的ED_(50)为0469 mg/kg(95%CI 0453~0486 mg/kg),ED_(95)为0542 mg/kg(95%CI 0519~0583 mg/kg)。与阴性组比较,阳性组苏醒时间明显延长(P<005)。两组无一例出现恶心、呕吐、注射痛、呼吸抑制、过敏等不良反应。结论复合羟考酮时环泊酚用于无痛人工流产术的ED_(50)为0469 mg/kg(95%CI 0453~0486 mg/kg),ED_(95)为0542 mg/kg(95%CI 0519~0583 mg/kg)。Objective To explore the median effective dose(ED_(50))of ciprofol when combined with oxycodone on painless abortion.Methods Twenty-three patients who underwent painless abortion surgery on a scheduled basis were selected,aged 22-40 years,BMI 20-30 kg/m^(2),ASA physical statusⅠorⅡ.Before anesthesia induction,0.08 mg/kg of oxycodone was injected intravenously,and the dose of ciprofol was adopted sequential.In the first patient,the dose of ciprofol was 0.6 mg/kg.The positive reaction of painless abortion is defined as a body movement reaction that occurs during the surgical process.If there was a positive reaction,the dose level was increased by one level,and if there was a negative reaction,the dose level was reduced by one level.The difference between adjacent doses was 0.05 mg/kg,the study was terminated until 7 inflection points were found.The ED_(50),95%effective dose(ED_(95))and corresponding 95%confidence interval(CI)of ciprofol combined with oxycodone on painless induced abortion were calculated.The patients were divided into two groups based on whether there was body movement during surgery:positive group and negative group.The time of disappearance of eyelash reflex,end of surgery,awakening time were recorded.The occurrence of intraoperative nausea,vomiting,injection pain,respiratory inhibition,and allergy were recorded.Results The ED_(50)of ciprofol for painless abortion was 0.469 mg/kg(95%CI 0.453-0.486 mg/kg),and the ED_(95)was 0.542 mg/kg(95%CI 0.519-0.583 mg/kg).Compared with negative group,the awakening time of the positive group was significantly prolonged.No adverse reactions such as nausea,vomiting,injection pain,respiratory inhibition,or allergies occurred in either group of patients.Conclusion When combined with oxycodone,the ED_(50)of ciprofol for painless abortion is 0.469 mg/kg(95%CI 0.453-0.486 mg/kg),and the ED_(95)of ciprofol for painless abortion is 0.542 mg/kg(95%CI 0.519-0.583 mg/kg).

关 键 词：环泊酚 羟考酮 无痛人工流产术 序贯法 半数有效剂量 

分 类 号：R614[医药卫生—麻醉学] R169.42[医药卫生—外科学]