疏风降胃方对肺胃气逆型咳嗽变异性哮喘气道炎症因子及肺功能的影响  

The Influence of Wind-Dispersing and Stomach-Suppressing Decoction on Airway Inflammatory Factors and Pulmonary Function in Cough Variant Asthma with Lung-Stomach Qi Counterflow Syndrome

作　　者：李友传 LI Youchuan(Zhengzhou Airport Zhenggang Hospital,Zhengzhou,Henan,China,451162)

机构地区：[1]郑州航空港郑港医院,河南郑州451162

出　　处：《河南中医》2023年第11期1696-1699,共4页Henan Traditional Chinese Medicine

基　　金：河南省科技攻关计划项目(202102310497)。

摘　　要：目的:探讨疏风降胃方对肺胃气逆型咳嗽变异性哮喘(cough variant asthma, CVA)气道炎症因子及肺功能的影响。方法:将86例CVA患者按照随机数字表法分为对照组和观察组,每组各43例。对照组给予沙美特罗替卡松粉吸入剂,观察组给予疏风降胃方治疗。比较两组患者治疗前后中医证候积分、气道炎症因子[白细胞介素-5(interleukin-5,IL-5)、外周血嗜酸性粒细胞(eosinophils, EOS)、嗜酸性粒细胞阳离子蛋白(eosinophil cationic protein, ECP)、痰液黏蛋白5AC(mucin5AC,MUC5AC)]和肺功能[第一秒用力呼气容积(forced expiratory volume in one second, FEV1)、呼气流量峰值(forced expiratory peak, PEF)及FEV1/FVC]变化情况。结果:两组患者治疗后中医证候积分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后IL-5、EOS、ECP、MUC5AC水平低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后FEV1、PEF、FEV1/FVC水平高于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。结论:疏风降胃方治疗肺胃气逆型CVA,可改善患者的临床症状及肺功能,也能有效缓解患者气道炎症因子水平。Objective:To observe the influence of Wind-Dispersing and Stomach-Suppressing Decoction on airway inflammatory factors and pulmonary function in Cough Variant Asthma(CVA)with lung-stomach qi counterflow syndrome.Methods:A total of 86 CVA pa-tients were divided into the control group and the observation group according to the random number table method,with 43 cases in each group.The control group was treated with Salmeteroticasone Powder Inhalant,while the observation group was treated with Wind-Disper-sing and Stomach-Suppressing Decoction.Then the changes in the TCM syndrome scores,airway inflammatory factors[interleukin-5(IL-5),peripheral blood Eosinophil(EOS),eosinophil cationic protein(ECP),mucin5AC(MUC5AC)]and lung function[including forced expiratory volume in one second(FEV1),forced expiratory peak(PEF)and FEV1/FVC] of the two groups before and after treatment were compared.Results:After treatment,the TCM syndrome scores of the two groups were lower than those of the same group before treatment,and the observation group's scores were lower than those of the control group after treatment,and the differences were statistically significant(P<0.05);The levels of IL-5,EOS,ECP,and MUC5AC in the two groups of were lower than those of the same group before treatment,and the observation group's above levels were lower than those of the control group,and all the differences were statistically significant(P<0.05);The levels of FEV1,PEF,and FEV1/FVC in the two groups were higher than those of the same group before treatment,and the observation group's above levels were lower than those of the control group,and all the differences were statistically significant(P<0.05).Conclusion:Wind-Dispersing and Stomach-Suppressing Decoction can improve the clinical symp-toms and lung function levels of CVA patients with lung-stomach qi counterflow syndrome,and also effectively alleviate the levels of air-way inflammatory factors.

关 键 词：咳嗽变异性哮喘 肺胃气逆证 疏风降胃方 沙美特罗替卡松粉吸入剂 

分 类 号：R259.622.5[医药卫生—中西医结合]