尼古丁和酒精依赖者自发性大脑活动静息态fMRI研究  

A resting-state fMRI study of spontaneous brain activity in persons dependent on both nicotine and alcohol

作　　者：王凌飞 张勇[1] 牛晓玉 高昕宇 张孟哲 汪卫建 程敬亮[1] WANG Lingfei;ZHANG Yong;NIU Xiaoyu;GAO Xinyu;ZHANG Mengzhe;WANG Weijian;CHENG Jingliang(Department of Magnetic Resonance,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450002,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450052

出　　处：《磁共振成像》2023年第11期1-5,24,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：河南省重点研发与推广专项(科技攻关)项目(编号:212102310712)。

摘　　要：目的通过探讨吸烟和饮酒状态对脑自发活动的影响,研究二者共病关联的神经生物学机制。材料与方法基于低频振幅(amplitude of low-frequency fluctuation,ALFF)方法,采用2×2因子设计,包括以下四组:饮酒/非饮酒的吸烟者(n=35/n=27)和饮酒/非饮酒的非吸烟者(n=21/n=25),进行静息态MRI扫描并计算ALFF,对四组ALFF值行方差分析(ANOVA)。在方差分析(ANOVA)的基础上进行事后检验(Bonferroni校正),以进一步了解不同组之间的具体差异。结果与健康对照组相比,吸烟组双侧楔前叶、右侧楔叶具有较高的ALFF值(t=3.212,P=0.001);而饮酒组左侧小脑半球具有较高的ALFF值(t=3.422,P=0.001),体素水平P<0.005,团块水平P<0.05,基于GRF校正。吸烟和饮酒共同影响左侧小脑后叶的脑活动,但效果相反。左侧小脑后叶的ALFF值与烟龄、吸烟指数和饮酒依赖量表分值均呈负相关(n=35;r=−0.367,P=0.025;r=−0.267,P=0.033;r=−0.293,P=0.026)。结论吸烟和饮酒都会影响自发性大脑活动,它们的交互作用出现在左侧小脑后叶。吸烟和饮酒会产生一种新的拮抗相互作用。这表明在研究吸烟者的自发大脑活动时,需要将饮酒作为一个变量进行控制。Objective:To investigate the effects of smoking and drinking on brain spontaneous activity and the neurobiological mechanism of comorbidity between smoking and drinking.Materials and Methods:Based on the amplitude of low-frequency fluctuation(ALFF)method,a 2×2 factorial design was employed to investigate the effects of alcohol on ALFF in individuals categorized into four groups:alcohol-consuming smokers(n=35)and alcohol-consuming non-smokers(n=27),as well as non-alcohol-consuming smokers(n=21)and non-alcohol-consuming non-smokers(n=25).Resting-state functional magnetic resonance imaging(fMRI)scans were performed to acquire brain data,and ALFF values were calculated for each group.Subsequently,an analysis of variance(ANOVA)was conducted to assess the differences in ALFF values among the four groups.To further explore specific group differences,post hoc tests(Bonferroni correction)were conducted based on the ANOVA results.The study aims to gain insights into the impact of alcohol consumption on ALFF in the context of nicotine dependence,contributing to a deeper understanding of neural activity and its modulation in addiction.Results:Compared with healthy controls,the smoking group had higher ALFF values in the bilateral precuneus and right cuneus(t=3.212,P=0.001),while the drinking group had higher ALFF values in the left cerebellar hemisphere(t=3.422,P=0.001),with P<0.005 for voxel levels and P<0.05 for mass levels,based on GRF correction.Smoking and alcohol consumption jointly affected brain activity in the left posterior cerebellar lobe,but with opposite effects.ALFF values in the left posterior cerebellar lobe were negatively correlated with smoking age,pack-years and drinking dependence scale scores(n=35;r=-0.367,P=0.025;r=-0.267,P=0.033;r=-0.293,P=0.026).Conclusions:Smoking and alcohol consumption both affect spontaneous brain activity,and their interaction occurs in the left posterior cerebellar lobe.Smoking and drinking produce a novel antagonistic interaction.This suggests that we need to control for alco

关 键 词：低频幅度 尼古丁成瘾 酒精成瘾 交互作用 静息态磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749[医药卫生—诊断学]