磁共振成像技术在抑郁症经颅磁刺激治疗靶点选择中的应用进展  

Advances in the application of magnetic resonance imaging in the localization of therapeutic targets for transcranial magnetic stimulation in depression

作　　者：罗昕 张宾 LUO Xin;ZHANG Bin(Psychological and Psychiatric Neuroimage Lab,Affiliated Brain Hospital of Guangzhou Medical University,Key Laboratory ofNeurogenetics and Channelopathies of Guangdong Province,the Ministry of Education of China,Guangzhou Medical University,Guangzhou 510370,China;Psychological and Psychiatric Lab,Tianjin Anding Hospital,Tianjin 300074,China)

机构地区：[1]广州医科大学附属脑科医院精神心理脑功能实验室广东省神经科学疾病研究重点实验室神经致病基因与离子通道病省部共建重点实验室,广州510370 [2]天津市安定医院精神心理研究所,天津300074

出　　处：《磁共振成像》2023年第11期150-154,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：广东省科技计划项目(编号:2019B030316001)。

摘　　要：经颅磁刺激(transcranial magnetic stimulation,TMS)是临床治疗抑郁症的常用方法,然而其疗效不一,这可能与刺激靶点的定位不同有关。近年来,随着磁共振成像(magnetic resonance imaging,MRI)技术的发展,利用MRI结构和功能像数据寻找TMS抗抑郁靶点成为当前的研究热点。因此,本文综述了MRI在TMS抗抑郁靶点选择中的应用进展,包括以下几个方面:利用MRI结构像可以进行更为精准的脑区划分及毫米级靶点坐标的定义;通过MRI功能像计算功能连接和有效连接等参数来确定个体化刺激靶点的位置;结合MRI结构像的辅助定位法帮助操作者准确定位到目标刺激靶点。本综述旨在整理相关研究,为提高TMS临疗效提供相关参考。Transcranial magnetic stimulation(TMS)is widely used in clinical interventions for depression,but its efficacy varies,possibly due to differences in target site localization.In recent years,with the development of magnetic resonance imaging(MRI)technology,the use of MRI structural and functional data to identify TMS targets for antidepressant effects has become a research hotspot.Therefore,this review summarized the application progress of MRI in TMS target site selection for depression treatment,including the following aspects:Precise brain region delineation and definition of millimeter-level target coordinates using MRI structural imaging;Determination of individualized stimulation target locations by calculating functional connectivity and effective connectivity parameters from MRI functional imaging;The use of MRI structural imaging for assisted targeting to help operators accurately locate the target stimulation sites.This review aims to compile relevant research and provide references for improving the clinical efficacy of TMS.

关 键 词：磁共振成像 经颅磁刺激 功能连接 任务态功能磁共振成像 抑郁症 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.4[医药卫生—诊断学]