多模态MRI在探究益生菌制剂改善2型糖尿病患者认知障碍机制中的研究进展  

Advancements in the multi-modal MRI study of probiotic formulations for ameliorating cognitive impairment in type 2 diabetes mellitus patients

作　　者：汪旭洋 许珊 杨东 林琳[1] 沈晶[1] 伍建林[1] WANG Xuyang;XU Shan;YANG Dong;LIN Lin;SHEN Jing;WU Jianlin(Department of Radiology,Affiliated Zhongshan Hospital of Dalian University,Dalian 116001,China)

机构地区：[1]大连大学附属中山医院放射科,大连116001

出　　处：《磁共振成像》2023年第11期159-163,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:82071911);大连市科技创新基金(编号:2021JJ12SN38)。

摘　　要：2型糖尿病(type 2 diabetes mellitus,T2DM)是最常见的糖尿病类型且多伴有不同程度认知功能障碍。研究证实肠道菌群与T2DM相关并发症存在密切联系,有望通过益生菌制剂干预来改善其认知功能障碍等并发症,并可利用多模态MRI技术实现其检测与评估。本文就该领域的研究现状与成果进展进行综述,旨在为T2DM认知障碍临床个体化诊疗提供新方向,并为T2DM肠-脑轴领域的研究提供新思路。Type 2 diabetes mellitus(T2DM)is the most common type of diabetes and is often accompanied by varying degrees of cognitive dysfunction.Research has shown a close relationship between the gut microbiota and the complications associated with T2DM.There is hope that cognitive dysfunction and other complications can be improved through the intervention of probiotics,and their assessment and evaluation can be achieved using multimodal MRI techniques.This article provides a comprehensive review of the current state of research and advancements in this field,aiming to offer new directions for personalized clinical diagnosis and treatment of cognitive impairments in T2DM and to provide new insights for research in the T2DM gut-brain-axis field.

关 键 词：2型糖尿病 认知障碍 益生菌 多模态磁共振成像 磁共振成像 肠-脑轴 

分 类 号：R445.2[医药卫生—影像医学与核医学] R781.64[医药卫生—诊断学]