关节软骨损伤磁共振定量成像的研究进展  

Research progress in quantitative magnetic resonance imaging of articular cartilage injury

作　　者：李薪茹 李伟[1] LI Xinru;LI Wei(Department of Imaging,Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010010,China)

机构地区：[1]内蒙古医科大学第二附属医院影像科,呼和浩特010010

出　　处：《磁共振成像》2023年第11期198-202,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：内蒙古自治区自然科学基金项目(编号:2022MS08012);内蒙古医科大学科技创新团队计划任务项目(编号:YKD2022TD034)。

摘　　要：关节的急性和慢性损伤都可引起不同程度的软骨损伤,早期的软骨损伤往往可以自行修复,中晚期损伤不可逆,随着病情进展,引发患者关节畸形或功能障碍,严重影响患者正常生活。目前常规的MRI技术很难准确评估软骨早期损伤,MRI定量技术能够分析软骨生化成分和超微结构变化,早期无创地精准评估软骨损伤。本文就关节骨软骨损伤的病理生理机制及无创性MRI定量评估技术的最新研究进展进行综述,以便临床早期诊断治疗,阻止软骨损伤的恶化或逆转其影响。The acute and chronic injuries of joints can cause different degrees of cartilage damage,early cartilage damage can often repair itself,and the middle and late damage is irreversible,with the progress of the disease,resulting in joint deformity or dysfunction,seriously affecting the normal life of patients.At present,it is difficult for conventional magnetic resonance imaging technology to accurately assess the early damage of cartilage.But quantitative MRI technology can accurately evaluate the early damage of cartilage non-invasive by analyzing the biochemical components and ultrastructural changes of cartilage.In this paper,the pathophysiological mechanism of osteocartilage injury and the latest research progress of non-invasive MRI quantitative evaluation technology are reviewed,so as to prevent the deterioration of cartilage injury or reverse its effects in early clinical diagnosis.

关 键 词：关节软骨 磁共振成像 T1ρ成像 T1弛豫时间成像 T2弛豫时间成像 扩散加权成像 扩散张量成像 扩散峰度成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R684[医药卫生—诊断学]