当归多糖抗肿瘤作用机制研究现状  

Research Progress on Anti-tumor Mechanism of Angelica Sinensis Polysaccharide

作　　者：王中会 闫平慧[1] 晁旭[1,3] WANG Zhonghui;YAN Pinghui;CHAO Xu(Shaanxi University of Chinese Medicine,Shaanxi 712046,China;Zhaotong Health Vocational College,Zhaotong 657600,China;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]昭通卫生职业学院,云南昭通657600 [3]陕西中医药大学第二附属医院,陕西咸阳712046

出　　处：《山东中医药大学学报》2023年第6期819-824,共6页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81774132);陕西中医药大学学科创新团队项目(批文号:陕中大学科办〔2019〕2号);陕西省科技计划项目(编号:2020SF-324)。

摘　　要：当归多糖是当归的主要活性成分,通过多种信号通路以及靶点发挥其细胞毒性,抑制肿瘤细胞的生长、增殖、侵袭迁移,诱导肿瘤细胞凋亡、周期阻滞、分化等。还可作为载体联合其他中药单体或化疗药制成纳米颗粒,靶向杀死肿瘤细胞。综述了当归多糖抗肿瘤作用的基础研究和分子机制,并对其在肿瘤防治中的应用前景进行展望。当归多糖由于其多种生物活性及低毒高效的抗肿瘤作用,有望成为一种新型抗癌药物。参考文献38篇。As the main active component of Danggui(Angelicae Sinensis Radix),Angelica Sinensis polysaccharide exert cytotoxicity through a variety of signaling pathways and targets,inhibit the growth,proliferation,invasion and migration of tumor cells,and induce apoptosis,cycle arrest and differentiation of tumor cells.It can also be used as a carrier in combination with other traditional Chinese medicine monomers or chemotherapy drugs to make nanoparticles to target and kill tumor cells.In this paper,the basic researches and molecular mechanism of anti-tumor effect of Angelica Sinensis polysaccharide were reviewed,and its application prospect in tumor prevention and treatment was forecasted.Angelica Sinensis polysaccharide is expected to become a new anticancer drug due to its various biological activities and low toxicity and high anti-tumor effect.There are 38 references in total.

关 键 词：当归多糖 抗肿瘤 细胞毒性 线粒体 表观遗传调控基因 免疫力 分子机制 

分 类 号：R282.710.7[医药卫生—中药学]