高原低氧环境影响胃肠道功能的因素及药物保护作用研究进展  

Progress on factors affecting gastrointestinal function and drug protection in high altitude hypoxia environment

作　　者：程俊飞 赵安鹏 赵以览 王子晗 李文斌 王荣 CHENG Junfei;ZHAO Anpeng;ZHAO Yilan;WANG Zihan;LI Wenbin;WANG Rong(Department of Pharmacy,the 940th Hospital of Joint Logistics Support force of CPLA,Lanzhou 730050,China;School of pharmacy,Lanzhou university,Lanzhou 730000,China)

机构地区：[1]联勤保障部队第九四〇医院药剂科,甘肃兰州730050 [2]兰州大学药学院,甘肃兰州730000

出　　处：《药学实践与服务》2023年第11期648-653,共6页Journal of Pharmaceutical Practice and Service

基　　金：国家自然科学基金(81673508);甘肃省自然科学基金(20JR5RA598);中央高校基本科研业务费专项(3192020009);甘肃省青年科技基金计划(20JR10RA014);联勤保障部队第九四〇医院院内课题(2021yxky065)。

摘　　要：由于高原环境具有低压、低氧和寒冷等因素,急进高原人群易患消化系统疾病,如上腹疼痛、食欲减退及恶心呕吐等胃肠道功能障碍,严重影响了急进高原人群的身体健康及高原作业能力。急进高原引起的胃肠道功能障碍主要体现在胃肠道运动功能障碍、黏膜屏障功能受损及肠道菌群失调3个方面。目前胃肠道功能障碍发病机制仍不十分明确,针对性预防和治疗的药物较少。笔者对近年来胃肠道激素、氧自由基与炎症因子和肠道菌群等影响因素及药物保护作用等方面的研究做出归纳总结,以期为防治急进高原引起的胃肠道应急反应提供治疗方案和理论依据。Due to factors such as low pressure,low oxygen and cold in the plateau environment,people who enter the plateau rapidly are susceptible to digestive system diseases,such as upper abdominal pain,loss of appetite,nausea and vomiting and other gastrointestinal dysfunction,which seriously affect the health and work ability of people who enter the plateau rapidly.The gastrointestinal dysfunction caused by the rapid advance to the plateau is mainly reflected in three aspects:gastrointestinal motility dysfunction,impaired mucosal barrier function,and intestinal flora imbalance.At present,the pathogenesis of gastrointestinal dysfunction is still not very clear,and there are fewer drugs for targeted prevention and treatment.Gastrointestinal hormones,oxygen free radicals,inflammatory factors,intestinal flora and other factors,as well as the protective effects of related drugs were reviewed in this paper to provide treatment options and theoretical basis for the prevention and treatment of the gastrointestinal emergency response caused by entering the plateau.

关 键 词：高原低氧 胃肠道运动 胃肠黏膜 肠道菌群 

分 类 号：R594.3[医药卫生—内科学]