糖尿病肾病患者血清1,25–二羟维生素D3、胱抑素C、载脂蛋白B水平变化及其临床意义  

Changes and role of serum 1,25-dihydroxyvitamin D3,Cystatin C and apolipoprotein B in patients with diabetic nephropathy

作　　者：苏晋锋 Su Jinfeng(Department of Endocrinology,Jincheng People’s Hospital,Jincheng 048000,China)

机构地区：[1]晋城市人民医院内分泌科,晋城048000

出　　处：《中国实用医刊》2023年第18期5-9,共5页Chinese Journal of Practical Medicine

摘　　要：目的探讨糖尿病肾病患者血清1,25–二羟维生素D_(3)[1,25(OH_(2))D_(3)]、胱抑素C(CysC)、载脂蛋白B(ApoB)水平变化及其临床意义。方法回顾性分析2021年10月至2022年10月晋城市人民医院收治的60例糖尿病患者的临床资料,根据有无糖尿病肾病将其分为研究A组(无糖尿病肾病,20例)及研究B组(糖尿病肾病,40例),另抽取60例同期健康体检者为对照组。比较三组研究对象血清1,25(OH_(2))D_(3)、ApoB及CysC水平;比较研究B组不同病情程度者血清1,25(OH_(2))D_(3)、ApoB及CysC水平;分析糖尿病肾病病情程度与1,25(OH_(2))D_(3)、ApoB及CysC水平的相关性;计算曲线下面积评估三项指标对糖尿病肾病的诊断价值。结果三组血清1,25(OH_(2))D_(3)水平比较,依次为研究B组<研究A组<对照组;三组ApoB、CysC水平比较,依次为研究B组>研究A组>对照组,三组血清1,25(OH_(2))D_(3)、ApoB及CysC水平比较差异有统计学意义(P<0.05)。糖尿病肾病病情程度与1,25(OH_(2))D_(3)呈负性相关,与ApoB及CysC呈正性相关(P<0.05)。血清1,25(OH_(2))D_(3)、ApoB、CysC预测糖尿病肾病的曲线下面积分别为0.80、0.79、0.85,截断值分别为13.39 ng/L、1.22 mg/L、1.46 mg/L;三者联合预测糖尿病肾病的曲线下面积为0.91。结论血清1,25(OH_(2))D_(3)、ApoB、CysC及三者联合检测对糖尿病肾病发生及进展具有较好预测价值。Objective To investigate the changes and role of serum 1,25-dihydroxyvitamin D_(3)[1,25(OH_(2))D_(3)],apolipoprotein B(ApoB)and cystatin C(CysC)in patients with diabetic nephropathy.Methods The clinical data of 60 patients with diabetes mellitus admitted to Jincheng People’s Hospital from October 2021 to October 2022 were retrospectively analyzed.According to the occurrence of diabetic nephropathy,the patients were divided into research group A(20 cases,without diabetic nephropathy)and research group B(40 cases,with diabetic nephropathy);and another 60 cases healthy people who underwent physical examination during the same period were selected as the control group.The levels of serum 1,25(OH_(2))D_(3),ApoB and CysC were compared among the three groups.The levels of serum 1,25(OH_(2))D_(3),ApoB,and CysC of patients with different disease degrees in research group B were compared.And the correlation between the severity of diabetic nephropathy and the levels of 1,25(OH_(2))D_(3),ApoB and CysC was analyzed.The area under the curve was calculated to evaluate the diagnostic value of them for diabetic nephropathy.Results The levels of serum 1,25(OH_(2))D_(3) of the three groups showed a increasing trend in the order of study group B,study A group and control group;the levels of ApoB and CysC among the three groups showed a decreasing trend in the order of study group B,study group A and control group.And there were statistically significant differences in the levels of serum 1,25(OH_(2))D_(3),ApoB and CysC among the three groups(P<0.05).The severity of diabetic nephropathy was negatively correlated with 1,25(OH_(2))D_(3),and was positively correlated with ApoB and CysC(P<0.05).The areas under the curve of serum 1,25(OH_(2))D_(3),ApoB,and CysC in predicting diabetic nephropathy were 0.80,0.79,and 0.85,respectively;and the cut-off values were 13.39 ng/L,1.22 mg/L,and 1.46 mg/L,respectively;the area under the curve of combination of three indicators in prediction of diabetic nephropathy was 0.91.Conclusions The detectio

关 键 词：糖尿病肾病 1 25–二羟维生素D3 胱抑素C 载脂蛋白B 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]