全膝关节置换术治疗膝关节内侧间室骨性关节炎的效果观察  

Observation of therapeutic effect of total knee arthroplasty on medial compartment osteoarthritis of knee joint

作　　者：张建锋[1] Zhang Jianfeng(Department of Joint Surgery,Puyang People’s Hospital,Puyang 457000,China)

机构地区：[1]濮阳市人民医院关节外科,濮阳457000

出　　处：《中国实用医刊》2023年第18期33-36,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨全膝关节置换术治疗膝关节内侧间室骨性关节炎的价值。方法抽取2019年6月至2022年6月濮阳市人民医院收治的80例膝关节骨性关节炎患者为研究对象,通过随机数字表法将纳入患者分为对照组与观察组,每组40例。对照组采用关节镜手术治疗,观察组采用全膝关节置换术治疗。比较两组治疗效果、手术指标(手术时间、术中出血量、住院时间、首次直腿抬高时)及并发症发生率,比较两组治疗前后炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平。结果观察组治疗总有效率(100.0%,40/40)高于对照组(90.0%,36/40),差异有统计学意义(P<0.05)。观察组手术时间、住院时间、首次直腿抬高时间短于对照组,术中出血量少于对照组(P<0.05)。术后,观察组CRP、IL-6、TNF-α水平低于对照组(P<0.05)。观察组并发症发生率(2.5%,1/40)低于对照组(17.5%,7/40),差异有统计学意义(P<0.05)。结论全膝关节置换术治疗膝关节内侧间室骨性关节炎的效果及安全性优于关节镜手术。Objective To investigate the clinical value of total knee arthroplasty in the treatment of medial compartment osteoarthritis of knee joint.Methods Eighty patients with knee osteoarthritis admitted to puyang People’s Hospital from June 2019 to June 2022 were selected as research objects,and they were divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated by arthroscopic surgery,and the observation group was treated by total knee arthroplasty.The clinical efficacy,operation related indexes(operation time,intraoperative blood loss,hospital stay and first straight leg raising time)and incidence of complications were compared between the two groups.The levels of inflammatory factors,including C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α),were compared between the two groups before and after treatment.Results The total effective rate in the observation group(100.0%,40/40)was higher than that in the control group(90.0%,36/40),P<0.05.The operation time,hospital stay and first straight leg raising time of the observation group were shorter than those of the control group,and the intraoperative blood loss was lower than that of the control group(P<0.05).The levels of CRP,IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.05).The incidence of surgery-related complications in the observation group(2.5%,1/40)was lower than that in the control group(17.5%,7/40),P<0.05.Conclusions Total knee arthroplasty has better therapeutic effect and safety on medial compartment osteoarthritis of knee joint than arthroscopic surgery.

关 键 词：全膝关节置换术 膝关节内侧间室骨性关节炎 关节镜手术 炎症因子 并发症 

分 类 号：R687.4[医药卫生—骨科学]