组织工程输尿管的研究进展及纺织技术应用前瞻  

Tissue engineered ureter:research progress and prospect of textile technology application

作　　者：赵文硕 胡梦博 李超婧 王璐[1,2] ZHAO Wenshuo;HU Mengbo;LI Chaojing;WANG Lu(College of Textiles,Donghua University,Shanghai 201620,China;Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry,Donghua University,Shanghai 201620,China;Department of Urology of Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]东华大学纺织学院,上海201620 [2]东华大学纺织行业生物医用纺织材料与技术重点实验室,上海201620 [3]复旦大学附属华山医院泌尿外科,上海200040

出　　处：《东华大学学报（自然科学版）》2023年第6期19-25,共7页Journal of Donghua University(Natural Science)

基　　金：高等学校学科创新引智计划(BP0719035);中央高校基本科研业务费专项资金(2232021G-01)。

摘　　要：现有的输尿管重建治疗方法因伴随狭窄、输尿管瘘等并发症及供体缺乏等问题,无法满足临床需求,组织工程为其提供了新的可行方法。回顾了国内外研究组织工程输尿管的主要构建策略、材料选择和制备方法,聚焦基于纺织技术的组织工程输尿管研发现状,总结得出输尿管重建存在良好重建效果与短期准备时间的矛盾,以及局部平滑肌生长受限等问题。通过纺织技术制备的微纳纤维集合体,能够控制纤维、纱线和织物多层级结构。进一步设计不同材料与纺织技术结合的多层级结构,并探究其对各类细胞行为的调控作用,这将为组织工程输尿管支架结构的优化设计提供新的方向。The existing ureteral reconstruction treatment methods are unable to meet the clinical needs due to complications such as stricture,ureteral fistula and lack of donor.Tissue engineering provides a new feasible method.The main construction strategies,material selection and preparation methods for the study of tissue-engineered ureter at home and abroad are reviewed.The review focused on the current status of the development of tissue-engineered ureter based on textile technology,and concluded that ureteral reconstruction suffered from the contradiction between good reconstructive effect and short-term preparation time,as well as limited local smooth muscle growth.Micro-nano fiber aggregates prepared by textile technology can control the multi-level structure of fibers,yarns and fabrics.Further design of multi-layered structures of different materials combined with textile technology and investigation of their modulating effects on the behavior of various types of cells will provide new directions for the optimal design of tissue-engineered ureteral scaffold structures.

关 键 词：输尿管 组织工程 纺织技术 静电纺丝 微纳纤维集合体 

分 类 号：TS101.4[轻工技术与工程—纺织工程]