款冬花多糖磁性纳米粒的制备工艺研究  

Preparation of Magnetic Nanoparticles of Tussilago farfara L.Polysaccharides

作　　者：叶世莉 刘思美 张丽华[1] 张婷婷[1] 郭可 赵鹏[1] YE Shili;LIU Simei;ZHANG Lihua;ZHANG Tingting;GUO Ke;ZHAO Peng(Shaanxi Key Laboratory of Traditional Chinese Medicine Foundation and New Drug Research,Shaanxi University of Chinese Medicine,Xianyang 712000,China;Shaanxi Institute of International Trade&Commerce,Xianyang 712000,China)

机构地区：[1]陕西中医药大学陕西中药基础与新药研究重点实验室,陕西咸阳712000 [2]陕西国际商贸学院,陕西咸阳712000

出　　处：《化学与生物工程》2023年第11期28-34,共7页Chemistry & Bioengineering

基　　金：陕西省重点研发计划项目(2022SF-389),陕西省重点实验室基金项目(21JS008,20JS034)。

摘　　要：采用化学共沉淀法制备了Fe_(3)O_(4)纳米粒子,将款冬花多糖与Fe_(3)O_(4)纳米粒子超声反应制备了款冬花多糖磁性纳米粒;以款冬花多糖磁性纳米粒粒径和分散系数(PDI)为考察指标,在单因素实验的基础上,运用Box-Behnken响应面法优化了款冬花多糖磁性纳米粒的制备工艺。结果表明,在m(款冬花多糖)∶m(Fe_(3)O_(4)纳米粒子)为1∶1.0、超声时间为30 min、超声功率为400 W的最佳条件下,款冬花多糖磁性纳米粒的粒径为678.6 nm、PDI为0.554,款冬花多糖磁性纳米粒中多糖含量为16.31%、铁含量为31.31%,为款冬花多糖的进一步应用奠定了基础。We firstly prepared Fe_(3)O_(4) nanoparticles by a chemical co\|precipitation method,and then prepared magnetic nanoparticles of Tussilago farfara L.polysaccharides(TFP)through the ultrasonic reaction of TFP with Fe_(3)O_(4) nanoparticles.Moreover,taking the particle size and dispersion index(PDI)of the magnetic nanoparticles as indexes,we optimized the preparation process of the magnetic nanoparticles by Box\|Behnken response surface methodologies on the basis of single\|factor experiments.The results show that,under the optimal conditions as follows:m(TFP)∶m(Fe_(3)O_(4) nanoparticles)of 1∶1.0,the ultrasonic time of 30 min,and the ultrasonic power of 400 W,the particle size and PDI of the magnetic nanoparticles are 678.6 nm and 0.554,respectively.The contents of polysaccharides and Fe in the magnetic nanoparticles are 16.31%and 31.31%,respectively.The study lays a foundation for the further application of TFP.

关 键 词：款冬花多糖 磁性纳米粒 制备工艺 响应面法 

分 类 号：O629.12[理学—有机化学]