那他霉素光降解杂质的制备与结构鉴定  

Preparation and Structure Identification of Photodegradation Impurity of Natamycin

作　　者：董月 于兰[1] 李晓露[1] 曹鹏然 林旸[1] 赵建强 DONG Yue;YU Lan;LI Xiaolu;CAO Pengran;LIN Yang;ZHAO Jianqiang(NCPC New Drug Research&Development Co.,Ltd.,National Engineering Research Center of Microbial Medicine,Hebei Industry Microbial Metabolic Technology Innovation Center,Shijiazhuang 052165,China;NCPC Huasheng Co.,Ltd.,Shijiazhuang 052160,China)

机构地区：[1]华北制药集团新药研究开发有限责任公司微生物药物国家工程研究中心河北省工业微生物代谢技术创新中心,河北石家庄052165 [2]华北制药华胜有限公司,河北石家庄052160

出　　处：《化学与生物工程》2023年第11期44-46,51,共4页Chemistry & Bioengineering

基　　金：河北省科技研发平台建设专项(22567651H)。

摘　　要：将那他霉素精品在光照强度5000 Lx下进行光降解,得到那他霉素光降解杂质粗品,采用制备液相色谱法对那他霉素光降解杂质粗品进行分离纯化,并通过MS和NMR等分析手段对其结构进行鉴定,确定该光降解杂质为那他霉素的C12位差向异构体。We obtained crude photodegradation impurity of Natamycin by photodegradation of refined Natamycin under light intensity of 5000 Lx.Moreover,we separated and purified the crude photodegradation impurity of Natamycin by preparative liquid chromatography.Furthermore,we identified the photodegradation impurity as the C12 epimer of Natamycin by MS and NMR analyses.

关 键 词：那他霉素 光降解杂质 分离纯化 结构鉴定 

分 类 号：TQ465.7[化学工程—制药化工]