穴位埋线治疗儿童脾虚肝旺型抽动障碍的临床疗效及对血清NSE水平的影响  

Acupoint thread-embedding for children with tic disorders of spleen deficiency and liver hyperactivity and its effect on serum level of NSE

作　　者：金玉晶 葛国岚 JIN Yu-jing;GE Guo-lan(Department of TCM,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou 450046,China)

机构地区：[1]河南省儿童医院郑州儿童医院中医科,郑州450046

出　　处：《中国针灸》2023年第11期1261-1265,共5页Chinese Acupuncture & Moxibustion

基　　金：2022年度河南省医学科技攻关计划联合共建项目:LHGJ20220723。

摘　　要：目的:观察穴位埋线治疗儿童脾虚肝旺型抽动障碍(TD)的临床疗效及对患儿血清神经元特异性烯醇化酶(NSE)水平的影响。方法:将68例脾虚肝旺型抽动障碍患儿随机分为观察组(34例,脱落1例)和对照组(34例,脱落3例、剔除1例)。观察组采用穴位埋线治疗,穴取百会及双侧合谷、太冲、脾俞、肝俞、曲池、足三里等,每4周治疗1次;对照组口服盐酸硫必利片治疗,每日2次。两组均治疗12周。比较两组患儿治疗前后耶鲁综合抽动严重程度量表(YGTSS)评分、血清NSE水平,并评定临床疗效。结果:治疗后,除对照组YGTSS发声抽动评分外,两组患儿YGTSS各项评分及总分、血清NSE水平均较治疗前降低(P<0.05),观察组患儿YGTSS各项评分及总分、血清NSE水平均低于对照组(P<0.05)。观察组总有效率为87.9%(29/33),高于对照组的76.7%(23/30,P<0.05)。结论:穴位埋线治疗脾虚肝旺型TD具有较好的临床疗效,能降低患儿YGTSS评分及血清NSE水平。Objective To observe the clinical efficacy of acupoint thread-embedding for children with tic disorders of spleen deficiency and liver hyperactivity and its effect on serum level of neuron-specific enolase(NSE).Methods A total of 68 children with tic disorders of spleen deficiency and liver hyperactivity were randomized into an observation group(34cases,1 case dropped out)and a control group(34 cases,3 cases dropped out,1 case was eliminated).In the observation group,acupoint thread-embedding was applied at Baihui(GV 20)and bilateral Hegu(LI 4),Taichong(LR 3),Pishu(BL 20),Ganshu(BL 18),Quchi(LI 11),Zusanli(ST 36),etc.,once every 4 weeks.In the control group,tiapride hydrochloride tablet was given orally,twice a day.Both groups were treated for 12 weeks.Before and after treatment,the Yale global tic severity scale(YGTSS)score and serum level of NSE were observed in the two groups,and the clinical efficacy was evaluated.Results After treatment,except for vocal tic score of YGTSS in the control group,the each-item scores and total scores of YGTSS and serum levels of NSE in the two groups were decreased compared with those before treatment(P<0.05);the eachitem scores and total score of YGTSS and serum level of NSE in the observation group were lower than those in the control group(P<0.05).The total effective rate in the observation group was 87.9%(29/33),which was higher than 76.7%(23/30)in the control group(P<0.05).Conclusion Acupoint thread-embedding has a good effect in the treatment of children with tic disorders of spleen deficiency and liver hyperactivity,could reduce the YGTSS score and serum level of NSE.

关 键 词：抽动障碍 脾虚肝旺型 穴位埋线 耶鲁综合抽动严重程度量表 神经元特异性烯醇化酶 

分 类 号：R246.4[医药卫生—针灸推拿学]