预期眼动任务中反应时呈双峰分布的神经环路模型  

A parallel neural circuit model for bimodal distribution of reaction time in a predictive saccade task

作　　者：章梦娅 雷力行 杨俊忠[2] 王大辉 ZHANG Mengya;LEI Lixing;YANG Junzhon;WANG Dahui(School of Systems Science,Beijing Normal University,100875,Beijing,China;School of Science,Beijing University of Posts and Telecommunications,100876,Beijing,China;State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,100875,Beijing,China;Beijing Key Laboratory of Brain Imaging and Connectomics,Beijing Normal University,100875,Beijing,China)

机构地区：[1]北京师范大学系统科学学院,北京100875 [2]北京邮电大学理学院,北京100876 [3]北京师范大学认知神经科学与学习国家重点实验室,北京100875 [4]北京师范大学神经影像大数据与人脑连接组学北京市重点实验室,北京100875

出　　处：《北京师范大学学报（自然科学版）》2023年第5期769-775,共7页Journal of Beijing Normal University(Natural Science)

基　　金：国家自然科学基金资助项目(32171094);国家重点科技研发计划资助项目(019YFA0709503)。

摘　　要：在执行精确时间内产生预期眼动的任务时,猕猴的反应时间呈现双峰分布.对这一现象,本文设计了包含大脑皮层的顶内沟外侧区(lateral intraparietal area,LIP)和辅助眼区(supplementary eye fields,SEF)、基底节(basal ganglia,BG)与上丘脑(superior colliculus,SC)在内的并行神经环路模型,通过计算模拟复现出双峰分布.本文探究了该分布的神经机制,发现SEF和LIP神经元群体之间的竞争过程导致了2个峰的出现,并且SEF脑区主要负责预期性眼动,主导了第1个峰的出现,LIP脑区主要负责由视觉刺激引发的反应性眼动,主导了第2个峰的出现.本文进一步地讨论了影响双峰分布形态的关键参数,从计算神经科学的角度探索了时间预期执行的过程.In predictive saccade tasks within precise time intervals,the reaction time of macaque exhibits a bimodal distribution.To investigate this phenomenon further,a parallel neural circuit model that includes the lateral intraparietal area(LIP),supplementary eye fields(SEF)in the cerebral cortex,the basal ganglia(BG)and superior colliculus(SC)is proposed in this study.Model simulations successfully reproduced a bimodal distribution.Competitive interaction among neuronal populations in SEF and LIP regions was found to give rise to two peaks.SEF region primarily was found to handle predictive saccades and dominated the first peak,while LIP region was found to be responsible for visually evoked reactive saccades and dominated the second peak.Key parameters that influence morphology of bimodal distribution are discussed.The process of time expectation from the perspective of computational neuroscience is explored.

关 键 词：预期眼动 反应时间 双峰分布 并行神经环路 神经动力学 

分 类 号：Q189[生物学—神经生物学]