低强度脉冲式超声波治疗勃起功能障碍的疗效评价  

Efficacy of low intensity pulsed ultrasound in the treatment of erectile dysfunction

作　　者：王京 孙国海 徐杨 赵晓智[1] 戴玉田[1] 徐志鹏[1] WANG Jing;SUN Guohai;XU Yang;ZHAO Xiaozhi;DAI Yutian;XU Zhipeng(Department of Andrology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210009,China)

机构地区：[1]南京大学医学院附属鼓楼医院男科,江苏南京210009

出　　处：《现代泌尿外科杂志》2023年第11期936-941,共6页Journal of Modern Urology

基　　金：江苏省省级重点研发计划专项资金(社会发展)项目(No.BE2019606)。

摘　　要：目的探讨低强度脉冲式超声波(LIPUS)治疗男性勃起障碍(ED)的疗效。方法回顾性分析2020年6月—2022年6月在南京大学医学院附属鼓楼医院就诊的ED患者121例。根据IIEF-EF评分将ED患者分为轻(17~25分)、中(11~16分)、重(0~10分)三个亚组。分析LIPUS治疗前、治疗后4周和12周时三组的总有效率、勃起硬度评级(EHS)、性生活日记问题(SEP)、总体评估问卷(GAQ)、收缩期峰值流速(PSV)、舒张末期流速(EDV)和不良反应等指标。结果119例患者完成随访。治疗后第4、12周与治疗前相比,IIEF-EF评分及EHS情况均有明显提升(P<0.05)。LIPUS治疗后第4、12周总有效率分别为69.75%、76.47%,治疗后4、12周轻度和中度组患者的总有效率均显著高于重度组(P<0.05)。SEP2、SEP3回答“能”的患者在治疗4周时分别为91.60%、71.43%,治疗后第12周占比分别为92.44%、78.15%,均显著高于治疗前(52.10%、27.73%,P<0.05)。GAQl和GAQ2在治疗后第4周回答“有”的患者占比分别为84.87%、71.43%,治疗后第12周分别为82.35%、70.59%,治疗后2次随访比较差异无统计学意义。患者在治疗后12周PSV水平较治疗前升高[(48.85±14.11)cm/s vs.(41.42±14.90)cm/s],差异有统计学意义(P<0.05);治疗后12周EDV水平较治疗前降低[(-0.57±7.01)cm/s vs.(2.25±5.68)cm/s],差异有统计学意义(P<0.05)。结论LIPUS对于ED患者具有良好的治疗效果且无明显不良反应。Objective To investigate the efficacy of low intensity pulsed ultrasound(LIPUS)in the treatment of erectile dysfunction(ED).Methods A total of 121 ED patients treated during June 2020 and June 2022 were selected as the research objects.According to the International Erectile Index Score(IIEF-EF),the patients were divided into three subgroups:mild(17-25 points),moderate(11-16 points),and severe(0-10 points).The total effective rate,erectile hardness scale(EHS),sex life log questions(SEP),general assessment questionnaire(GAQ),peak systolic velocity(PSV),end diastolic velocity(EDV),and adverse reactions of the three groups before treatment,4 weeks and 12 weeks after treatment were analyzed.Results A total of 119 patients completed the follow-up.There were significant increases in IIEF-EF and EHS at week 4 and 12(P<0.05),and the total effective rate was 69.75%and 76.47%,respectively.The total effective rate was significantly higher in the mild and moderate groups than in the severe group at week 4 and 12(P<0.05).The patients who answered“yes”to SEP2 and SEP3 accounted for 91.60%and 71.43%,respectively at week 4,and 92.44%and 78.15%at week 12,both significantly higher than the rates before treatment(52.10%and 27.73%,P<0.05).The proportion of patients who answered“yes”to GAQl and GAQ2 at week 4 were 84.87%and 71.43%,respectively,and were 82.35%and 70.59%respectively at week 12,with no significant difference.The PSV level significantly increased at week 12 compared to that before treatment[(48.85±14.11)cm/s vs.(41.42±14.90)cm/s](P<0.05),while the EDV level significantly decreased[(-0.57±7.01)cm/s vs.(2.25±5.68)cm/s](P<0.05).Conclusion LIPUS can improve erectile function in ED patients without obvious adverse reactions.

关 键 词：勃起功能障碍 低强度脉冲式超声波 阴茎彩色双功能多普勒检查 不良反应 性生活日记 国际勃起功能指数评分 

分 类 号：R698.1[医药卫生—泌尿科学]