伴Stauffer综合征肾癌患者17例诊治分析  

A retrospective clinical analysis of 17 cases of renal cell carcinoma with Stauffer syndrome

作　　者：刘艳霞 赵虎[2] 张立进 雒强 LIU Yanxia;ZHAO Hu;ZHANG Lijin;LUO Qiang(Department of Pathology,Jiangyin People's Hospital,Affiliated Jiangyin Hospital of the Southeast University Medical College,Jiangyin 214400,China;Department of Urology,Jiangyin People's Hospital,Affiliated Jiangyin Hospital of the Southeast University Medical College,Jiangyin 214400,China)

机构地区：[1]江阴市人民医院病理科,江苏江阴214400 [2]江阴市人民医院泌尿外科,江苏江阴214400

出　　处：《现代泌尿外科杂志》2023年第11期947-951,共5页Journal of Modern Urology

摘　　要：目的探讨伴Stauffer综合征的肾癌患者的诊疗及预后。方法回顾性分析2014年9月—2019年8月于江阴市人民医院接受手术治疗的17例伴Stauffer综合征的肾癌患者的临床病理资料及随访结果。通过Kaplan-Meier法及log-rank检验进行生存分析,单因素和多因素Cox回归分析影响肾癌患者预后的相关因素。结果17例患者中术后病理结果为透明细胞癌者14例,乳头状肾细胞癌2例,组织分化差、类型难定者1例。手术后3个月内肝功能恢复正常者5例,6个月内恢复者3例,1年内恢复者4例,持续未恢复者3例。17例患者术后随访6~72个月,平均54.1个月,术后1、3、5年生存率分别为88.2%(15/17)、76.5%(13/17)、52.9%(9/17)。生存分析显示伴Stauffer综合征的肾癌患者肿瘤特异性生存率偏低,且肿瘤大小、美国癌症联合委员会(AJCC)分期、淋巴结转移和Stauffer综合征是肾癌患者的不良预后因素。结论伴Stauffer综合征的肾癌患者整体预后较差,应早期手术干预。术后多数患者肝功能可逐渐恢复正常,连续监测肝功能对肿瘤的复发、转移及患者预后有重要的指导意义。Objective To explore the diagnosis,treatment and prognosis of renal cell carcinoma(RCC)patients with Stauffer syndrome.Methods The clinicopathological and follow-up data of 17 RCC patients with Stauffer syndrome who underwent operation during Sep.2014 and Aug.2019 were retrospectively analyzed.The survival was analyzed with Kaplan-Meier curve and log-rank,and related factors affecting the prognosis were determined with univariate and multivariate Cox regression model.Results The pathological results included clear cell RCC in 14 cases,papillary RCC in 2 cases,and poorly differentiated tissue in 1 case.The liver function recovered within 3 months after operation in 5 cases,within 6 months in 3 cases,within 1 year in 4 cases,and did not recover in 3 cases.During the follow up of 6 to 72(average 54.1)months,the 1-,3-,and 5-year survival rates were 88.2%(15/17),76.5%(13/17)and 52.9%(9/17),respectively.Survival analysis showed that the cancer-specific survival(CSS)of RCC patients with Stauffer syndrome was low,and tumor size,AJCC stage,lymph node metastasis and Stauffer syndrome were predictors of poor prognosis.Conclusion The prognosis of RCC patients with Stauffer syndrome is poor,and early surgical intervention should be conducted.The liver function of most patients can return to normal gradually after surgery.Continuous examination of liver function has significant meaning for tumor recurrence,metastasis and prognosis.

关 键 词：肾癌 Stauffer综合征 副瘤综合征 

分 类 号：R692.9[医药卫生—泌尿科学]