天然产物色胺酮的研究进展  

Research progress of natural product tryptanthrin

作　　者：廖维 宋娇 韩丽[1] 张定堃[1] LIAO Wei;SONG Jiao;HAN Li;ZHANG Ding-kun(State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院,西南特色中药资源国家重点实验室,成都611137

出　　处：《天然产物研究与开发》2023年第11期2003-2013,共11页Natural Product Research and Development

基　　金：国家自然科学基金面上项目(82173976);国家重点研发计划(2018YFC1707205);江西中医药大学创新药物与高效节能降耗制药设备国家重点实验室开放基金课题(GZSYS202003)。

摘　　要：色胺酮是一种天然的吲哚喹唑啉类生物碱,是许多中草药的生物活性成分之一,如青黛Indigo Naturalis、大青叶Isatidis Folium和板蓝根Isatidis Radix。色胺酮的抗菌、抗炎作用早有报道,近期研究发现其还具有抗肿瘤、抗病毒、抗血管生成、抗寄生虫等药理活性。加之结构稳定、毒副作用小、易于被肠道吸收等特点,使之成为当前的一个研究热点。本文重点归纳总结了色胺酮的药理活性,并对其天然来源,合成方法,体内吸收、分布、代谢及毒性研究进展进行综述,以期为色胺酮的进一步研究、开发利用提供较为全面的文献信息支持。Tryptanthrin is a natural indolequinazoline alkaloid,is one of the bioactive components of many traditional Chinese herbal medicines,such as Indigo Naturalis,Isatidis Folium and Isatidis Radix.The antibacterial and anti-inflammatory effects of tryptanthrin have been reported for a long time.Recently,some studies have found that it also has anti-tumor,anti-virus,anti-angiogenesis,anti-parasitic and other pharmacological activities.Coupled with the characteristics of stable structure,low toxic and side effects,and easy absorption by the intestinal tract,it has become a current research hotspot.This review focused on the pharmacological activities of tryptanthrin,and at the same time summarized its natural sources,synthetic methods,as well as absorption,distribution,metabolism and toxicity in vivo.It is expected to provide a more comprehensive literature information support for the further research,development and utilization of tryptanthrin.

关 键 词：色胺酮 药理作用 来源 代谢 毒性 

分 类 号：R961[医药卫生—药理学]