血清炎症因子联合PSA、f-PSA可辅助诊断前列腺癌  

Serum inflammatory factors combined with PSA and f-PSA in the auxiliary diagnosis of prostate cancer

作　　者：彭伟[1] 李运改 许静[1] 刘华[1] 杨翠霞[1] 沈云岳[1] PENG Wei;LI Yungai;XU Jing;LIU Hua;YANG Cuixia;SHEN Yunyue(Department of Clinical Laboratory,Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital,Shanghai 200233,China)

机构地区：[1]上海交通大学医学院附属第六人民医院检验科,上海200233

出　　处：《检验医学》2023年第9期849-854,共6页Laboratory Medicine

基　　金：国家自然科学基金项目(82273462);国家自然科学基金项目(81974445)。

摘　　要：目的探讨血清炎症因子联合前列腺特异性抗原(PSA)、游离前列腺特异性抗原(f-PSA)检测在前列腺癌辅助诊断中的临床价值。方法选取2020年7月—2022年11月上海交通大学医学院附属第六人民医院前列腺癌患者49例(前列腺癌组)、前列腺增生患者50例(前列腺增生组)、健康体检者33名(正常对照组)。检测所有对象血清肿瘤坏死因子α(TNF-α)、白细胞介素(IL)1β、白细胞介素2受体(IL-2R)、IL-8、IL-10、PSA和f-PSA水平。收集前列腺癌患者的临床资料。采用受试者工作特征(ROC)曲线评估各项指标单项检测和联合检测诊断前列腺癌的效能。结果前列腺癌组血清TNF-α、IL-8水平显著高于正常对照组和前列腺增生组(P<0.05);前列腺增生组血清TNF-α水平显著高于正常对照组(P<0.05)。3个组之间血清IL-1β、IL-2R和IL-10水平差异均无统计学意义(P>0.05)。不同年龄、Gleason评分、TNM分期、国际泌尿病理协会(ISUP)分级和有无高血压史、糖尿病史,以及是否伴神经浸润的前列腺癌患者之间血清TNF-α、IL-8水平差异均无统计学意义(P>0.05)。以正常对照组+前列腺增生组作为对照,ROC曲线分析结果显示,TNF-α、IL-8、PSA和f-PSA单项检测诊断前列腺癌的AUC分别为0.704、0.642、0.892、0.811,TNF-α+IL-8+PSA+f-PSA+f-PSA/PSA比值联合检测的AUC为0.946,显著高于单项检测和其他联合检测组合(P<0.05)。结论血清TNF-α、IL-8、PSA、f-PSA和f-PSA/PSA比值联合检测有助于提高前列腺癌的诊断效率。Objective To investigate the clinical value of serum inflammatory factors with prostatespecific antigen(PSA)and free prostate-specific antigen(f-PSA)in the auxiliary diagnosis of prostate cancer.Methods From July 2020 to November 2022,49 prostate cancer patients(prostate cancer group),50 prostate hyperplasia patients(benign prostate hyperplasia group)and 33 healthy subjects(healthy control group)were enrolled from Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital.The serum levels of tumor necrosis factor-alpha(TNF-α),interleukin(IL)-1β,interleukin-2 rceptor(IL-2R),IL-8,IL-10,PSA and f-PSA were determined,and the clinical data of prostate cancer patients were collected.The efficacy of single and combined determinations of various indicators in the diagnosis of prostate cancer was evaluated by receiver operating characteristic(ROC)curve.Results The serum levels of TNF-αand IL-8 in prostate cancer group were higher than those in healthy control group and benign prostate hyperplasia group(P<0.05).The serum levels of TNF-αin benign prostate hyperplasia group were higher than those in healthy control group(P<0.05).There was no statistical significance in serum levels of IL-1β,IL-2R and IL-10 among the 3 groups(P>0.05).The serum levels of TNF-αand IL-8 in prostate cancer patients with different ages,Gleason scores,TNM stages,the International Society of Urological Pathology(ISUP)grades,hypertension history,diabetes mellitus history and nerve invasion had no statistical significance(P>0.05).Using the healthy control group and the benign prostate hyperplasia group as control,ROC curve analysis results showed that the areas under curves(AUC)of TNF-α,IL-8,PSA and f-PSA single determinations for diagnosing prostate cancer were 0.704,0.642,0.892 and 0.811,respectively,and the AUC for the combined determination of TNF-α,IL-8,PSA,f-PSA and f-PSA/PSA ratio was 0.946,which was higher than the other AUC(P<0.05).Conclusions The combined determination of serum TNF-α,IL-8,PSA,f-PSA and f-PSA

关 键 词：肿瘤坏死因子α 白细胞介素8 前列腺特异性抗原 炎症因子 前列腺癌 

分 类 号：R446.1[医药卫生—诊断学]