AFP、CYFRA 21-1、ProGRP水平联合检测在恶性孤立性肺结节诊断中的价值  

Value of combined detection of AFP,CYFRA21-1 and ProGRP levels in diagnosis of malignant solitary pulmonary nodules

作　　者：胡泊 HU Bo(Department of Pathology of Xuchang Central Hospital,Xuchang 461000 Henan,China)

机构地区：[1]许昌市中心医院病理科,河南许昌461000

出　　处：《中国民康医学》2023年第21期107-109,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析甲胎蛋白(AFP)、细胞角蛋白19片段(CYFRA21-1)、胃泌素释放肽前体(ProGRP)水平联合检测在恶性孤立性肺结节诊断中的价值。方法:回顾性分析2021年3月至2023年3月该院收治的217例孤立性肺结节患者的临床资料,根据病理结果将其分为良性结节组143例与恶性结节组74例。另选取同期该院217名健康体检者作为对照组。比较三组血清AFP、CYFRA21-1、ProGRP水平,采用Spearman相关性分析AFP、CYFRA21-1、ProGRP水平与恶性孤立性结节的相关性,绘制受试者工作特征曲线(ROC)分析血清AFP、CYFRA21-1、ProGRP水平联合检测诊断恶性孤立性肺结节的价值。结果:三组血清AFP、CYFRA21-1、ProGRP水平比较,恶性结节组>良性结节组>对照组,差异均有统计学意义(P<0.05);经Spearman相关性分析结果显示,血清AFP、CYFRA21-1、ProGRP水平与恶性孤立性肺结节均呈正相关(r>0,P<0.05);ROC曲线分析结果显示,血清AFP、CYFRA21-1、ProGRP水平单项及联合检测诊断恶性孤立性肺结节的曲线下面积(AUC)分别为0.766、0.747、0.772、0.923,均具有一定诊断价值,且联合检测诊断价值高于三者单项检测。结论:血清AFP、CYFRA21-1、ProGRP水平联合检测诊断恶性孤立性肺结节的价值高于三者单项检测。Objective:To analyze value of combined detection of alpha-fetoprotein(AFP),cytokeratin 19 fragment(CYFRA21-1)and pro-gastrin-releasing peptide(ProGRP)levels in diagnosis of malignant solitary pulmonary nodules.Methods:The clinical data of 217 patients with solitary pulmonary nodules admitted to this hospital from March 2021 to March 2023 were retrospectively analyzed.According to the pathological results,they were divided into benign nodule group(143 cases)and malignant nodule group(74 cases).In addition,217 healthy subjects in the same period were selected as the control group.The levels of serum AFP,CYFRA21-1 and ProGRP were compared among the three groups.Spearman correlation analysis was used to analyze the correlations among the AFP,CYFRA21-1,ProGRP levels and malignant nodules.The receiver operating characteristic curve(ROC)was drawn to analyze the value of combined detection of serum AFP,CYFRA21-1 and ProGRP levels in the diagnosis of malignant solitary pulmonary nodules.Results:The comparison of the levels of serum AFP,CYFRA21-1 and ProGRP in each group showed that:the malignant nodule group>the benign nodule group>the control group,and the differences were statistically significant(P<0.05).The Spearman correlation analysis showed that serum AFP,CYFRA21-1,and ProGRP levels were positively correlated with malignant solitary pulmonary nodules(r>0,P<0.05).The ROC curve analysis showed that the areas under the curve(AUC)of single and combined detection of serum AFP,CYFRA21-1 and ProGRP levels in the diagnosis of malignant solitary pulmonary nodules were 0.766,0.747,0.772 and 0.923,separately,all of which had certain diagnostic value,and the diagnostic value of combined detection was higher than that of single detection.Conclusions:The value of combined detection of serum AFP,CYFRA21-1 and ProGRP levels in the diagnosis of malignant solitary pulmonary nodules is higher than that of single detection of the three.

关 键 词：恶性孤立性肺结节 甲胎蛋白 细胞角蛋白19片段 胃泌素释放肽前体 检测 诊断 价值 

分 类 号：R563[医药卫生—呼吸系统]