氯沙坦钾联合复方石韦颗粒治疗慢性肾小球肾炎的临床疗效及对患者血清炎症因子水平的影响  

Efficacy of losartan potassium combined with Fufang Shiwei granules in the treatment of chronic glomerulonephritis and the influence on serum inflammatory factor levels in patients

作　　者：罗萍[1] 刘杨武[1] 蒋玲 LUO Ping;LIU Yangwu;JIANG Ling(School of Medicine,Hunan University of Environment and Biology,Hengyang,Hunan,421001,China;Department of Cardiology,Hengyang Central Hospital,Hengyang,Hunan,421001,China)

机构地区：[1]湖南环境生物职业技术学院医学院,湖南衡阳421001 [2]衡阳市中心医院心内科,湖南衡阳421001

出　　处：《当代医学》2023年第21期10-13,共4页Contemporary Medicine

摘　　要：目的探究氯沙坦钾联合复方石韦颗粒治疗慢性肾小球肾炎的临床疗效及对患者血清炎症因子[白细胞诱素-1(LKN-1)、白细胞介素-33(IL-33)及肿瘤坏死因子-α(TNF-α)]水平的影响。方法选取2019年1月至2020年12月衡阳市中心医院收治的95例慢性肾小球肾炎患者作为研究对象,按照随机数字表法分为观察组(n=47)与对照组(n=48)。对照组单用氯沙坦钾治疗,观察组采用氯沙坦钾联合复方石韦颗粒治疗,比较两组临床疗效、治疗前后尿常规指标[尿红细胞计数(RBC)、24 h尿蛋白定量(24 h Upro)、尿β_(2)-微球蛋白(β_(2)-MG)]和血清炎症因子水平及急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)、健康状况调查简表(SF-36)评分。结果观察组治疗总有效率为95.74%,明显高于对照组的72.92%,差异有统计学意义(P<0.05)。治疗后,两组RBC、24 h Upro、β_(2)-MG水平均明显低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清LKN-1、IL-33及TNF-α水平均明显低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组APACHEⅡ评分均明显低于治疗前,SF-36评分均明显高于治疗前,且观察组APACHEⅡ评分低于对照组,SF-36评分高于对照组,差异有统计学意义(P<0.05)。两组治疗过程中均未发生明显不良反应。结论氯沙坦钾联合复方石韦颗粒治疗慢性肾小球肾炎效果显著,能改善患者肾功能,降低血清LKN-1、IL-33及TNF-α水平,提高患者健康状况及生命质量。Objective To investigate the clinical efficacy of losartan potassium combined with Fufang Shiwei granules in the treatment of chronic glomerulonephritis and the influence on serum inflammatory factor(leukotactin-1[LKN-1],interleukin-33[IL-33]and tumour necrosis factor-α[TNF-α])levels in patients.Methods 95 patients with chronic glomerulonephritis admitted to Hengyang Central Hospital from January 2019 to December 2020 were selected as the study subjects,and they were divided into the observation group(n=47)and the control group(n=48)according to the random number table method.The control group was treated with losartan potassium,and the observation group was treated with losartan potassium combined with Fufang Shiwei granules,the clinical efficacy,urine routine index(urine red blood cell count[RBC],24 h urine protein quantification[24 h Upro],β_(2)-microglobulin[β_(2)-MG])and serum inflammatory factor levels,and the acute physiology and chronic health evaluationscoring systemⅡ(APACHEⅡ),the MOS 36-item short form health survey(SF-36)scores were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.74%,which was significantly higher than 72.92%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of RBC,24 h Upro andβ_(2)-MG of the two groups were significantly lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the serum levels of LKN-1,IL-33 and TNF-αof the two groups were significantly lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the APACHEⅡscores of the two groups were significantly lower than before treatment,and the SF-36 scores were significantly higher than before treatment,and the APACHEⅡscore in the observation group was lower than that in the control

关 键 词：氯沙坦钾 复方石韦颗粒 慢性肾小球肾炎 白细胞诱素-1 白细胞介素-33 肿瘤坏死因子-Α 

分 类 号：R692.31[医药卫生—泌尿科学]